SnCl2/RSH: A versatile catalytic system for the synthesis of 4-Alkylsulfanyl-indazole derivatives
The treatment of alkylated nitro derivatives of indazole with stannous chloride in alkanethiol gave after coupling of the obtained amines with 4-methoxybenzenesulfonyl chloride in pyridine the new N-(4-Alkylsulfanylindazol-7-yl)-4-methoxybenzene sulfonamides via the nucleophilic substitution of hydrogen in position 4 of indazole, together with the expected 4-methoxy-N-(indazol-7-yl)-benzenesulfonamides. All the newly synthesized compounds have been characterized by elemental analysis and spectroscopic data.
Kouakou, Assoman,Chicha, Hakima,Rakib, El Mostapha,Gamouh, Ahmed,Hannioui, Abdellah,Chigr, Mohammed,Viale, Maurizio
p. 86 - 95
(2015/10/20)
Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors
We herein describe a new synthesis of N-(7-indazolyl)benzenesulfonamide derivatives. These compounds were evaluated for their antiproliferative activities toward L1210 murine leukemia cells. One of them, 4-methoxy-N-(3- chloro-7-indazolyl)benzenesulfonamide, was identified as the most potent with an IC50 of 0.44 μM.
Synthesis of 4-substituted and 3,4-disubstituted indazole derivatives by palladium-mediated cross-coupling reactions
The synthesis of 4-substituted indazole derivatives by palladium-mediated cross-coupling reactions was described. Suzuki, Heck, Sonogashira and Stille cross-coupling reactions were used to introduce aryl, vinyl and alkynyl substituents in 4-position of in
El Kazzouli, Sa?d,Bouissane, Latifa,Khouili, Mostafa,Guillaumet, Gérald
p. 6163 - 6167
(2007/10/03)
New and efficient synthesis of bi- and trisubstituted indazoles
In this paper, the synthesis of bi- and trisubstituted indazoles was described. 4-Alkoxy-7-aminoprotected-indazole or 7-aminoprotected-indazole derivatives were prepared selectively using SnCl2 in alcohol or SnCl2 in ethyl acetate, r
Bouissane, Latifa,El Kazzouli, Sa?d,Léger, Jean-Michel,Jarry, Christian,Rakib, El Mostapha,Khouili, Mostafa,Guillaumet, Gérald
p. 8218 - 8225
(2007/10/03)
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