864867-60-7Relevant articles and documents
Synthesis and characterization of Imidazo [1,2-a]pyridines and Zolimidine
Kushwaha, Narva Deshwar,Mondal, Somnath,Sharma, Renu,Kumar, Naresh
, p. 1495 - 1498 (2017/05/29)
A convenient and efficient synthesis, without any organic solvent or catalyst is described for the preparation of imidazo [1,2-a] pyridine derivatives. The reaction has been done between 2-aminopyridines and α-bromoacetone derivatives in good to excellent yields in water. In several cases the isolation does not require any chromatography for purification. The reaction thus developed has been applied for quick synthesis of zolimidine with 91 % yield.
DIARYL-SUBSTITUTED FIVE-MEMBERED HETEROCYCLE DERIVATIVE
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Page/Page column 38, (2010/11/24)
The present invention provides the compounds represented by formula (I): (I) or pharmaceutical salts thereof, wherein: X 1 represents oxygen atoms and the like, X 2 represents nitrogen atoms and the like, X 3 represents nitrogen atoms and the like, X 4 represents nitrogen atoms and the like, R 1 represents formula (II-1): wherein X 5 represents sulfur atoms and the like, A 1 represents carbon atoms and the like, A 2 represents nitrogen atoms and the like and A ring represents phenyl group and the like, having mGluR1 inhibiting effect, and being usefull for preventing or treating convulsion, acute pain, inflammatory pain, chronic pain, brain disorder such as cerebral infarction or transient ischemick attack, psychotic disorder such as schizophrenia, anxiety, drug dependence, Parkinson's disease, or gastrointestinal disorder.