Nickel-Catalyzed Sonogashira Coupling Reactions of Nonactivated Alkyl Chlorides under Mild Conditions
The two nickel chlorides1and2with [P,S] and [P,Se] bidentate ligands, respectively, were synthesized and used as catalysts for Sonogashira coupling reaction. Both1and2are efficient catalysts for Sonogashira C(sp3)-C(sp) coupling reactions. Comp
Preparation of 3-substituted-2-pyridin-2-ylindoles: regioselectivity of Larock's indole annulation with 2-alkynylpyridines
A regioselective Larock approach to 3-substituted-2-pyridin-2-ylindoles from 2-alkynylpyridines and 2-iodoanilines is described herein. The unexpectedly high regioselectivity can be rationalized by a combination of steric, coordinative and electronic effects.
Roschangar, Frank,Liu, Jianxiu,Estanove, Emilie,Dufour, Marine,Rodríguez, Sonia,Farina, Vittorio,Hickey, Eugene,Hossain, Azad,Jones, Paul-James,Lee, Heewon,Lu, Bruce Z.,Varsolona, Richard,Schr?der, Jürgen,Beaulieu, Pierre,Gillard, James,Senanayake, Chris H.
p. 363 - 366
(2008/09/17)
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