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(4,7-BIS-CARBOXYMETHYL-10-[(2-MERCAPTO-ETHYLCARBAMOYL)-METHYL]-1,4,7,10TETRAAZA-CYCLODODEC-1-YL)-ACETIC ACID, also known as DO3A-Thiol, is a DOTA derivative characterized by its unique structure that includes carboxylate and thiol functional groups. This molecule is designed for site-specific biomolecular modification through click chemistry, allowing for the targeted attachment of various biomolecules, such as peptides, proteins, and nucleic acids.
Used in Bioconjugation Applications:
DO3A-Thiol is used as a bioconjugation agent for the site-specific attachment of biomolecules. Its carboxylate and thiol functional groups enable the formation of stable covalent bonds with target biomolecules, allowing for precise control over the orientation and spatial arrangement of these molecules.
Used in Radiopharmaceutical Development:
In the field of radiopharmaceuticals, DO3A-Thiol is used as a chelating agent for the development of radiolabeled biomolecules. Its ability to form stable complexes with radiometals, such as copper-64 and gallium-68, enables the production of radiotracers for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging.
Used in Drug Delivery Systems:
DO3A-Thiol is also employed in the development of targeted drug delivery systems. By attaching therapeutic agents to biomolecules via DO3A-Thiol, it is possible to enhance the specificity and efficacy of drug delivery, reducing off-target effects and improving treatment outcomes.
Used in Diagnostic and Therapeutic Applications:
In the medical field, DO3A-Thiol is used for the development of diagnostic and therapeutic agents. Its ability to form stable complexes with various imaging agents and therapeutic payloads allows for the creation of multifunctional agents capable of both imaging and treating specific diseases.
Used in Research and Development:
DO3A-Thiol is utilized in research and development for the creation of novel biomolecular constructs and the study of biomolecular interactions. Its versatility in forming stable covalent bonds with a wide range of biomolecules makes it a valuable tool for exploring new applications and advancing scientific knowledge.

865470-67-3

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  • (4,7-BIS-CARBOXYMETHYL-10-[(2-MERCAPTO-ETHYLCARBAMOYL)-METHYL]-1,4,7,10TETRAAZA-CYCLODODEC-1-YL)-ACETIC ACID

    Cas No: 865470-67-3

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865470-67-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 865470-67-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,5,4,7 and 0 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 865470-67:
(8*8)+(7*6)+(6*5)+(5*4)+(4*7)+(3*0)+(2*6)+(1*7)=203
203 % 10 = 3
So 865470-67-3 is a valid CAS Registry Number.

865470-67-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[4,7-bis(carboxymethyl)-10-[2-oxo-2-(2-sulfanylethylamino)ethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:865470-67-3 SDS

865470-67-3Downstream Products

865470-67-3Relevant articles and documents

CATIONIC MICELLES AND METHODS FOR USING THEM

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Page/Page column 52-53, (2020/12/30)

The present invention relates to cationic micelles, and in particular the compounds capable of forming such cationic micelles for use in cell tracking.

Synthesis and DNA-binding studies of a dinuclear gadolinium(iii)-Platinum(ii) complex

Fenton, Jacob M.,Busse, Madleen,Rendina, Louis M.

, p. 576 - 580 (2015/04/27)

The synthesis and characterisation of a new dinuclear GdIII-PtII complex (1·PF6) containing a functionalised macrocyclic 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid derivative linked to a PtII-terpy (terpy≤2,2′:6′,

Improved syntheses and applicability of different DOTA building blocks for multiply derivatized scaffolds

Waengler,Waengler,Eisenhut,Haberkorn,Mier

, p. 2606 - 2616 (2008/12/22)

DOTA (1,4,7,10-tetraazacyclodocecane-N,N′,N″,N?-tetraacetic acid), which forms extremely stable complexes with a large number of metal ions, is one of the most important and most commonly used chelators for in vivo applications such as cancer diagnosis an

Derivatization of phosphopeptides with mercapto- and amino-functionalized conjugate groups by phosphate elimination and subsequent Michael addition

Mattila, Kati,Siltainsuu, Jaana,Balaspiri, Lajos,Ora, Mikko,Loennberg, Harri

, p. 3039 - 3044 (2007/10/03)

Kinetics of the β-elimination of the phosphate group from H-Tyr-Ser(PO3H2)-Phe-OH and H-Tyr-Thr(PO3H 2)-Phe-OH and subsequent addition of thiols and amines to the dehydroalaninyl and β-methyldehydroalaninyl resi

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