Carbamates as potent calcitonin gene-related peptide antagonists with improved solution stability
The calcitonin gene-related peptide (CGRP) receptor has been implicated in the pathogenesis of migraine. A class of urethanamide derivatives has been identified as potent inhibitors of the CGRP receptor. Compound 20 was found to be among the most potent (
Degnan, Andrew P.,Conway, Charles M.,Dalterio, Richard A.,Macci, Robert,Mercer, Stephen E.,Schartman, Richard,Xu, Cen,Dubowchik, Gene M.,Macor, John E.
scheme or table
p. 3555 - 3558
(2010/03/31)
Novel therapeutic agents for the treatment of migraine
The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their u
-
Page/Page column 32-33
(2010/02/14)
More Articles about upstream products of 865626-76-2
Get Best Price for865626-76-2(R)-3-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl 4-nitrophenyl carbonate