865774-07-8 Usage
Methyl ester derivative
1H-Imidazole-1-acetic acid this indicates that the compound is derived from 1H-imidazole-1-acetic acid by attaching a methyl ester group.
Nitro group present
4-nitro the compound contains a nitro group (-NO2) attached to the 4th position of the imidazole ring, which influences its chemical reactivity and properties.
Application in organic synthesis
commonly used 1H-Imidazole-1-acetic acid, α,α-dimethyl-4-nitro-, methyl ester is frequently utilized in the synthesis of various organic compounds, making it a valuable reagent in chemical research.
Application in pharmaceutical research
potential building block the compound has the potential to be used as a building block for the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals, making it important for the development of new drugs and therapeutic agents.
Health and safety risks
handle with care due to its chemical structure and reactivity, 1H-Imidazole-1-acetic acid, α,α-dimethyl-4-nitro-, methyl ester may pose potential health and safety risks if not properly managed or handled.
Check Digit Verification of cas no
The CAS Registry Mumber 865774-07-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,5,7,7 and 4 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 865774-07:
(8*8)+(7*6)+(6*5)+(5*7)+(4*7)+(3*4)+(2*0)+(1*7)=218
218 % 10 = 8
So 865774-07-8 is a valid CAS Registry Number.
865774-07-8Relevant articles and documents
Diamide amino-imidazoles: A novel series of γ-secretase inhibitors for the treatment of Alzheimers disease
Brodney, Michael A.,Auperin, David D.,Becker, Stacey L.,Bronk, Brian S.,Brown, Tracy M.,Coffman, Karen J.,Finley, James E.,Hicks, Carol D.,Karmilowicz, Michael J.,Lanz, Thomas A.,Liston, Dane,Liu, Xingrong,Martin, Barbara-Anne,Nelson, Robert B.,Nolan, Charles E.,Oborski, Christine E.,Parker, Christine P.,Richter, Karl E.G.,Pozdnyakov, Nikolay,Sahagan, Barbara G.,Schachter, Joel B.,Sokolowski, Sharon A.,Tate, Barbara,Van Deusen, Jeffrey W.,Wood, Douglas E.,Wood, Kathleen M.
scheme or table, p. 2631 - 2636 (2011/06/20)
The synthesis and structure-activity relationship (SAR) of a novel series of di-substituted imidazoles, derived from modification of DAPT, are described. Subsequent optimization led to identification of a highly potent series of inhibitors that contain a β-amine in the imidazole side-chain resulting in a robust in vivo reduction of plasma and brain Aβ in guinea pigs. The therapeutic index between Aβ reductions and changes in B-cell populations were studied for compound 10h.
IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
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Page/Page column 48; 50, (2010/02/14)
The present invention relates to compounds of the Formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and A are as defined. Compounds of the Formula (I) have activity inhibiting produ
