Spatially-addressable immobilization of macromolecules on solid supports
A method is described for immobilization of receptors, antibodies, or other macromolecules at precise locations on solid substrates. We have combined photolithographic techniques with the use of a 'caged' biotin analogue that has been covalently linked to
Sundberg, Steven A.,Barrett, Ronald W.,Pirrung, Michael,Lu, Amy L.,Kiangsoontra, Benjang,Holmes, Christopher P.
Synthesis and evaluation of photolabile insulin prodrugs
We have developed two photolabile insulin prodrugs, insulin-2P and insulin-3P. These prodrugs were synthesized by protecting GlyA1 (N αA1), and one or both of the PheB1 (NαB1) and LysB29 (NεB29) amino groups in insulin usi
Li, Lian-Sheng,Babendure, Jennie L.,Sinha, Subhash C.,Olefsky, Jerrold M.,Lerner, Richard A.