86701-12-4Relevant articles and documents
NEW METHODS AND REAGENTS IN ORGANIC SYNTHESIS. 51. A SYNTHESIS OF ASCIDIACYCLAMIDE, A CYTOTOXIC CYCLIC PEPTIDE FROM ASCIDIAN - DETERMINATION OF ITS ABSOLUTE CONFIGURATION
Hamada, Yasumasa,Kato, Shinji,Shioiri, Takayuki
, p. 3223 - 3226 (1985)
A first synthesis of ascidiacyclamide, a cytotoxic cyclic peptide from ascidian, has been achieved through the cyclodimerization with diphenyl phosphorazidate (DPPA), wich has unambiguously determined the absolute configuration of ascidiacyclamide as 1.
IN VITRO PRODUCTION OF CYCLIC PEPTIDES
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Sheet 26/29, (2015/11/28)
This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from Prochloron spp. Before cyclisation, residues in the linear peptide substrates may be heterocyclised using isolated cyanbacterial heterocyclases, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.
