- Tecarfarin preparation method
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The invention provides a new Tecarfarin preparation method, which comprises: carrying out acyl chlorination on 4-carboxybenzaldehyde, carrying out condensation with 1,1,1,3,3,3-hexafluoro-2-methylpropan-2-ol to form an ester, and carrying out a reaction o
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- Preparation method of tecarfarin
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The invention relates to a preparation method of tecarfarin. The method comprises the steps of adopting formylbenzoic acid and 4-hydroxycoumarin as substrates, carrying out addition reaction, and condensing with 1,1,1,3,3,3-hexafluoro-tert-butanol to obtain the end product tecarfarin. According to the method, esterolysis impurities caused by condensation reaction carried out at high temperature in the prior art is avoided, the purity and the yield are greatly improved, and the method is simple to operate, convenient to post-process, and suitable for industrial production.
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Paragraph 0041; 0042; 0043; 0044; 0045; 0046; 0047-0052
(2017/09/29)
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