- A Short, Efficient, Highly Selective Synthesis of (1R,3S)-cis-Chrysanthemic Acid through the Microbiological Reduction of 2,2,5,5-Tetramethyl-1,4-cyclohexanedione
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A highly selective synthesis of (1R,3S)-cis-chrysanthemic acid (1a), a key intermediate in the industrial prepariation of major unnatural pyrethrinoid-type insecticides is reported. 2,2,5,5-Tetramethyl-1,4-cyclohexanedi
- d'Angelo, Jean,Revial, Gilbert,Azerad, Robert,Buisson, Didier
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- SYNTHESE DE L'ACIDE CIS CHRYSANTHEMIQUE
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A simple, efficient approach of racemic cis chrysanthemic acid 2, an intermediate in the synthesis of the exceptionally potent insecticide Deltamethrine 1, is described.The key-intermediate of this approach was the 2,2,5,5-tetramethylcyclohexane 1,4-dione 5 which has been related to the lactone 3, a precursor of 2, in four steps (70 percent overall yield).
- d'Angelo, Jean,Revial, Gilbert
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p. 2103 - 2106
(2007/10/02)
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