868393-66-2

Basic information

• Product Name: methyl 4-hydroxy-2-methyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1,1-dioxide
• Synonyms: methyl 4-hydroxy-2-methyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1,1-dioxide;Albb-008914
• CAS NO: 868393-66-2
• Molecular Formula: C9H9NO5S2
• Molecular Weight: 275.3
• Mol File: 868393-66-2.mol

Chemical Properties

• Melting Point: 242 °C
• Boiling Point: 445.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.841±0.06 g/cm3(Predicted)
• PKA: 1.69±0.20(Predicted)
• CAS DataBase Reference: methyl 4-hydroxy-2-methyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-hydroxy-2-methyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1,1-dioxide(868393-66-2)
• EPA Substance Registry System: methyl 4-hydroxy-2-methyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1,1-dioxide(868393-66-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 868393-66-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4-hydroxy-2-methyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1,1-dioxide is used as a potential pharmaceutical compound for its possible pharmacological properties. The presence of hydroxy and methyl groups, along with the carboxylate and dioxide functional groups, may contribute to its interaction with biological targets, making it a candidate for drug development.
Used in Organic Synthesis:
In the field of organic synthesis, methyl 4-hydroxy-2-methyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1,1-dioxide can be utilized as a building block or intermediate in the synthesis of more complex organic molecules. Its unique ring system and functional groups may facilitate the creation of novel compounds with specific applications in various industries.

Upstream product

• 59804-37-4 tenoxicam 
• 868522-78-5 2-{[(4-hydroxy-2-methyl-1,1-dioxido-2H-thieno[2,3-e][1,2]thiazine-3-yl)carbonyl]amino}-1-methylpyridinium 

Relevant articles and documents

Novel chemical transformations of tenoxicam

Both N- and O-substituted derivatives of the anti-inflammatory drug tenoxicam (= 4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine- 3-carboxamide 1,1-dioxide; 1) were synthesized, and various chemical transformations were investigated. Bot

THE HYDROLYSIS OF TENOXICAM IN ACIDIC AND ALKALINE SOLUTIONS AND ITS STABILITY IN ARTIFICIAL GASTRIC AND INTESTINAL MEDIA

The degradation of tenoxicam in acidic (pH 1) and alkaline (pH 10) solutions at 100 deg C was investigated.Two degradation products were detected on thin-layer chromatogram.Due to the greater degradation in acidic pH than in alkaline pH the main degradation product was separated from acidic solution by using TLC and purified by preparative thin-layer chromatography.The structure of this product was elucidated as 2-aminopyridine by use of related UV, IR, NMR and MS.It was found that the degradation of tenoxicam in acidic and alkaline solutions at 100 deg C obeys thefirst order kinetics.The reaction rate constants (k hour-1) and chemical half-lives (t1/2) were calculated.Moreover the stability of pure tenoxicam and of its commercial preparations in artificial gastric and intestinal media with or without enzymes were investigated at 37 deg C.This study suggested that using alcohol in tenoxicam treatment may cause a reduction in the bioavailability and an enhancement in its side effects. - Keywords: Tenoxicam hydrolysis; Degradation kinetics; Degradation Product; Product Elucidation; Gastrointestinal degradation.