Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. the impact of physicochemical properties on ADME and PK
HIV-1 integrase is one of three enzymes encoded by the HIV genome and is essential for viral replication, and HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Recently, we reported the discovery of azaindole hydroxamic acids that
Tanis, Steven P.,Plewe, Michael B.,Johnson, Ted W.,Butler, Scott L.,Dalvie, Deepak,Delisle, Dorothy,Dress, Klaus R.,Hu, Qiyue,Huang, Buwen,Kuehler, Jon E.,Kuki, Atsuo,Liu, Wen,Peng, Qinghai,Smith, Graham L.,Solowiej, Jim,Tran, Khanh T.,Wang, Hai,Yang, Anle,Yin, Chunfeng,Yu, Xiaoming,Zhang, Junhu,Zhu, Huichun
supporting information; experimental part
p. 7429 - 7434
(2011/02/26)
INHIBITORS OF THE HIV INTEGRASE ENZYME
The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIV”) integrase enzyme.
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Page/Page column 142
(2008/06/13)
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