869886-87-3

Basic information

• Product Name: 5-chloro-4-iodo-N-isopropylpyridin-2-aMine
• Synonyms: 5-chloro-4-iodo-N-isopropylpyridin-2-aMine;5-Chloro-4-iodo-N-isopropyl-2-pyridinamine;2-Pyridinamine, 5-chloro-4-iodo-N-(1-methylethyl)-
• CAS NO: 869886-87-3
• Molecular Formula: C₈H₁₀ClIN₂
• Molecular Weight: 296.53587
• Mol File: 869886-87-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-chloro-4-iodo-N-isopropylpyridin-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-4-iodo-N-isopropylpyridin-2-aMine(869886-87-3)
• EPA Substance Registry System: 5-chloro-4-iodo-N-isopropylpyridin-2-aMine(869886-87-3)

Safety Data

• Hazardous Substances Data: 869886-87-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-4-iodo-N-isopropylpyridin-2-amine is used as a building block for novel drug candidates in medicinal chemistry research and drug discovery efforts. Its unique structure and reactivity make it a valuable component in the development of new pharmaceuticals.
Used in Agrochemical Industry:
5-Chloro-4-iodo-N-isopropylpyridin-2-amine may have potential applications in the development of herbicides, pesticides, and other agricultural chemicals. Its unique structure and reactivity can contribute to the creation of effective and targeted agrochemicals.
Used in Organic Synthesis:
5-Chloro-4-iodo-N-isopropylpyridin-2-amine is used as an intermediate in the synthesis of complex organic molecules. Its unique structure and reactivity make it a valuable component in industrial chemical processes for the production of various organic compounds.
It is important to handle 5-chloro-4-iodo-N-isopropylpyridin-2-amine with appropriate caution and safety measures due to its potential hazards and reactivity.

Upstream product

• 659731-48-3 5-chloro-2-fluoro-4-iodopyridine 
• 75-31-0 isopropylamine 

Downstream Products

• 869886-89-5 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1-(2,4,6-trimethylbenzenesulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 869886-67-9 4-[5-chloro-2-[(1-methylethyl)amino]-4-pyridinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide 
• 869886-90-8 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1H pyrrole-2-carboxylic acid 
• 1956366-10-1 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylic acid [1-(3-chlorophenyl)-2-hydroxyethyl]amide hydrochloride 
• 1956366-10-1 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylicacid[1-(3-chlorophenyl)-2-hydroxyethyl]amide hydrochloride 
• 869886-88-4 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester 

Relevant articles and documents

ERK INHIBITOR AND USE THEREOF

Disclosed are a compound (as shown in formula I) as an extracellular signal-regulated kinase (ERK) inhibitor, a pharmaceutical composition thereof, a preparation method therefor, and use thereof in treating ERK-mediated diseases. Said compound plays a role by regulating a plurality of processes such as cell proliferation, apoptosis, migration and angiogenesis.

TRICYCLIC COMPOUNDS AND THEIR USE

Tricyclic compounds and their use are provided. More specifically, tricyclic compounds, pharmaceutical compositions containing them, methods for preparing them, and their use in therapy are also provided.

CRYSTALLINE FORMS OF C21H22CI2N4O2

The present invention provides crystalline forms of a compound of formula (I). Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer. It has been discovered that crystalline forms of 4-(5-Chloro-2- isopropylaminopyridin-4-yl)-1 H-pyrrole-2-carboxylic acid [1 -(3-chlorophenyl)-2- hydroxyethyl]amide can be prepared which exhibit improved properties, e.g. surprisingly improved stability and improved solubility characteristics. Thus, the present invention provides crystalline 4-(5-Chloro-2- isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylic acid [1 -(3-chlorophenyl)-2- hydroxyethyljamide.

CRYSTALLINE C21H22C12N4O2 MALONATE

The present invention provides a malonate salt of a compound of formula (I), which is a crystalline salt. Also provided are pharmaceutical compositions that include the provided malonate salt and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

PYRROLE COMPOUNDS AS INHIBITORS OF ERK PROTEIN KINASE, SYNTHESIS THEREOF AND INTERMEDIATES THERETO

The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.