ANTIULCER 2-GUANIDINO-4-(2-SUBSTITUTED-AMINO-4-IMIDAZOLYL)THIAZOLES AND PROCESS THEREFOR
Heretofore unavailable 2-guanidino-4-(2-substituted-amino-4-imidazolyl) thiazoles; a novel process therefor, also advantageous for the preparation of known antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl) thiazoles; intermediate compounds therefor; and a method for treatment of ulcers in mammals therewith.
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(2008/06/13)
An Improved Preparation and Use of 2-Bromoacetoacetaldehyde in a New Synthesis of 2-Substituted-4-acetylimidazoles
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Lipinski, Christopher A.,Blizniak, Thaddeus E.,Craig, Rebecca H.
p. 566 - 570
(2007/10/02)
SYNTHESIS OF DERIVATIVES OF 3-OXOBUTANAL CONTAINING FUNCTIONAL GROUPS IN THE MESOMETHYLENE UNIT
The synthesis of 2-bromo-3-oxobutanal was realized by the bromination of 1-dialkylamino-1-buten-3-ones.The trans-enol form predominates in solutions.The direct nitration of 1,1-diethoxy-3-butanol leads to 2-nitro-3-oxobutanal.
Zaichenko, Yu. A.,Kormer, M. V.,Vil'davskaya, A. I.,Rall', K. B.,Maretina, I. A.
p. 818 - 820
(2007/10/02)
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