The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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(2013/09/12)
PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES
Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.
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(2013/09/12)
AMIDO-BENZYL SULFONE AND SULFONAMIDE DERIVATIVES
Disclosed are certain amido-benzyl sulfone and sulfonamide compounds, pharmaceutical compositions comprising such compounds, land methods of treatment using such compounds.
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(2013/09/12)
AMIDO-BENZYL SULFOXIDE DERIVATIVES
The present invention relates to certain amido-benzyl sulfoxide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment of an NAMPT-mediated disease or condition in a subject, selected from solid or liquid tumor, rheumat
The present invention relates to certain alkyl- and di-substituted amido-benzyl sulfonamide compounds, pharmaceutical compositions comprising such compounds, and to methods of treatment of NAMPT-mediated disorders, such as diabetes, rheumatoid arthritis,
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(2013/09/12)
Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N- hydroxybenzamide with high selectivity for the HDAC6 isoform
A screen for HDAC6 inhibitors identified acyl derivatives of 4-(aminomethyl)-N-hydroxybenzamide as potent leads with unexpected selectivity over the other subtypes. We designed and synthesized constrained heterocyclic analogues such as tetrahydroisoquinolines that show further enhanced HDAC6 selectivity and inhibitory activity in cellular assays. Selectivity may be attributed to the benzylic spacer more effectively accessing the wider channel of HDAC6 compared to other HDAC subtypes as well as hydrophobic capping groups interacting with the protein surface near the rim of the active site.
Blackburn, Christopher,Barrett, Cynthia,Chin, Janice,Garcia, Kris,Gigstad, Kenneth,Gould, Alexandra,Gutierrez, Juan,Harrison, Sean,Hoar, Kara,Lynch, Chrissie,Rowland, R. Scott,Tsu, Chris,Ringeling, John,Xu, He
p. 7201 - 7211
(2013/10/21)
SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF
This invention provides compounds of formula (/): wherein R1, R2, G, n, p and q have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the comp
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Page/Page column 98; 99
(2011/01/12)
THIADIAZOLE MODULATORS OF PKB
The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the th
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Page/Page column 134
(2009/03/07)
KINASE INHIBITORS AS THERAPEUTIC AGENTS
A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.
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Page/Page column 286
(2010/02/14)
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