870257-96-8Relevant articles and documents
Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase
Smith II, Leon,Wong, Wai C.,Kiselyov, Alexander S.,Burdzovic-Wizemann, Sabina,Mao, Yunyu,Xu, Yongjiang,Duncton, Matthew A.J.,Kim, Ki,Piatnitski, Evgueni L.,Doody, Jacqueline F.,Wang, Ying,Rosler, Robin L.,Milligan, Daniel,Columbus, John,Balagtas, Chris,Lee, Sui Ping,Konovalov, Andrey,Hadari, Yaron R.
, p. 5102 - 5106 (2007/10/03)
Novel tricyclic derivatives containing an oxazepine, thiazepine, or diazepine ring were studied for their EGFR tyrosine kinase inhibitory activity. While the oxazepines were in general more potent than thiazepines, the diazepines displayed somewhat differ
Preparation of substituted pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines via a Pictet-Spengler cyclization
Duncton, Matthew A. J.,Smith II, Leon M.,Burdzovic-Wizeman, Sabina,Burns, Aaron,Hu Liu, Yunyu Mao,Wong, Wai C.,Kiselyov, Alexander S.
, p. 9629 - 9631 (2007/10/03)
A synthesis of the title compounds, which have found use as inhibitors of certain receptor tyrosine kinases, was achieved using a Pictet-Spengler cyclization as a key step.
