- Sulfone Group as a Versatile and Removable Directing Group for Asymmetric Transfer Hydrogenation of Ketones
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The sulfone functional group has a strong capacity to direct the asymmetric transfer hydrogenation (ATH) of ketones in the presence of [(arene)Ru(TsDPEN)H] complexes by adopting a position distal to the η6-arene ring. This preference provides a
- Clarkson, Guy J.,Vyas, Vijyesh K.,Wills, Martin
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p. 14265 - 14269
(2020/07/04)
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- Water content influences the selectivity of CALB-catalyzed kinetic resolution of phenoxymethyl-substituted secondary alcohols
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Derivatives of 1-phenoxy-2-alkanols were kinetically resolved by esterification with irreversible and reversible acyl donors using lipase B from Candida antarctica (Novozyme 435) as a catalyst. To optimize the relative rate of reaction (the E-value), esterifications in eight different solvents with different water activities were performed. For 3-bromo-1-phenoxy-2-propanol (1), the E-values in all the solvents were higher when the water activity was increased, while the E-values for 1-phenoxy-2-pentanol (2) and 3-chloro-1-phenoxy-2-propanol (3) decreased by increasing water activity. The water content of the various reaction media with the same water activity was determined. Solvents such as 1,4-dioxane, acetonitrile, and tetrahydrofuran contained much more water than hexane, carbon tetrachloride, cyclohexane, toluene, and benzene. At high-water activity, the high-water content of the former group of solvents resulted in termination of the reaction at low conversion. The reason seemed to be that the acyl donor and possibly also the produced esters were hydrolyzed. This was not the case when the esterification was performed in water-immiscible solvents with the same water activity.
- Jacobsen, Elisabeth Egholm,Anthonsen, Thorleif
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p. 577 - 581
(2007/10/03)
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- SYNTHESIS AND SEVERAL TRANSFORMATIONS OF 1-ARYL ETHERS OF 1,2-PENTANEDIOL
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The reaction of 1-bromo-2-pentanol with substituted phenols in alkaline medium yield 1-aryl ethers of 1,2-pentanediol.The condensation of these ethers with α-chloroethers, carboxylic acid chlorides, and aromatic isocyanates gives the corresponding derivat
- Gasanov, V. S.,Alekperov, R. K.
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p. 1073 - 1077
(2007/10/02)
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