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3-AZATRICYCLO[4.2.1.0(2,5)]NON-7-ENE-3-CARBOXYLIC ACID-4-OXO-1,1-DIMETHYLETHYL ESTER is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

871357-90-3

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871357-90-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 871357-90-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,1,3,5 and 7 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 871357-90:
(8*8)+(7*7)+(6*1)+(5*3)+(4*5)+(3*7)+(2*9)+(1*0)=193
193 % 10 = 3
So 871357-90-3 is a valid CAS Registry Number.

871357-90-3Downstream Products

871357-90-3Relevant articles and documents

Development and scale-up of an optimized route to the ALK inhibitor CEP-28122

Allwein, Shawn P.,Roemmele, Renee C.,Haley, James J.,Mowrey, Dale R.,Petrillo, Daniel E.,Reif, James J.,Gingrich, Diane E.,Bakale, Roger P.

, p. 148 - 155 (2012/05/20)

Evolution of the process strategies to prepare CEP-28122, an anaplastic lymphoma kinase (ALK) inhibitor, is presented. The initial medicinal chemistry route, used for the preparation of key supplies for biological screening, is reviewed. In addition, the

Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases

Curtin, Michael L.,Robin Heyman,Frey, Robin R.,Marcotte, Patrick A.,Glaser, Keith B.,Jankowski, James R.,Magoc, Terrance J.,Albert, Daniel H.,Olson, Amanda M.,Reuter, David R.,Bouska, Jennifer J.,Montgomery, Debra A.,Palma, Joann P.,Donawho, Cherrie K.,Stewart, Kent D.,Tse, Chris,Michaelides, Michael R.

scheme or table, p. 4750 - 4755 (2012/08/07)

In an effort to identify kinase inhibitors with dual KDR/Aurora B activity and improved aqueous solubility compared to the Abbott dual inhibitor ABT-348, a series of novel pyrazole pyrimidines structurally related to kinase inhibitor AS703569 were prepared. SAR work provided analogs with significant cellular activity, measureable aqueous solubility and moderate antitumor activity in a mouse tumor model after weekly ip dosing. Unfortunately these compounds were pan-kinase inhibitors that suffered from narrow therapeutic indices which prohibited their use as antitumor agents.

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