871507-60-7Relevant articles and documents
Efficient multikilogram synthesis of 5-bromo-2-cyclopropyl-1-methyl-1H- imidazole
Frutos, Rogelio P.,Rodriguez, Sonia,Patel, Nitinchandra,Johnson, Joe,Saha, Anjan,Krishnamurthy, Dhileepkumar,Senanayake, Chris H.
, p. 1076 - 1078 (2007)
Herein we describe the optimization and application of a copper(I) chloride-mediated protocol for the multikilogram synthesis of 5-bromo-2-cyclopropyl-1-methyl-1H-imidazole hydrochloride (1), a key building block used in the preparation of several biologically active small molecules.
HETEROARYL CARBOXAMIDE COMPOUNDS AS INHIBITORS OF RIPK2
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Paragraph 0244, (2018/03/25)
The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Y, and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these
Expedient synthesis of substituted imidazoles from nitriles
Frutos, Rogelio P.,Gallou, Isabelle,Reeves, Diana,Xu, Yibo,Krishnamurthy, Dhileepkumar,Senanayake, Chris H.
, p. 8369 - 8372 (2007/10/03)
Expedient and practical new methodology for the synthesis of substituted imidazoles was developed to provide a rapid access to a variety of 2-substituted, 1,2-disubstituted and 1,2,4-trisubstituted imidazoles by the direct CuCl-mediated reaction of nitriles with α-amino acetals in an intermolecular as well as intramolecular fashion.
