- New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part one: [h]-fused tricyclic systems
-
The synthesis and SAR of a new series of potent and selective dopamine D3 receptor antagonists is reported. The introduction of a tricyclic [h]-fused benzazepine moiety on the recently disclosed scaffold of 1,2,4-triazol-3-yl-thiopropyl-tetrahy
- Micheli, Fabrizio,Bonanomi, Giorgio,Braggio, Simone,Capelli, Anna Maria,Celestini, Paolo,Damiani, Federica,Fabio, Romano Di,Donati, Daniele,Gagliardi, Stefania,Gentile, Gabriella,Hamprecht, Dieter,Petrone, Marcella,Radaelli, Stefano,Tedesco, Giovanna,Terreni, Silvia,Worby, Angela,Heidbreder, Christian
-
-
Read Online
- COMPOUNDS HAVING AFFINITY FOR DOPAMINE D3 RECEPTOR AND USES THEREOF
-
Compounds of formula (I) and salts thereof are disclosed: wherein A, R1, m, R2, n, R3, R4, q, W1, W2, R5 and R6 are as defined in the description. Methods of preparing the compounds and uses thereof in medicine, for example in the treatment of schizophrenia or drug dependency, are also disclosed.
- -
-
Page/Page column 49-51
(2010/02/15)
-