871723-37-4Relevant articles and documents
HPK1 ANTAGONISTS AND USES THEREOF
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Paragraph 1316; 1319, (2021/03/19)
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.
Pd-Catalyzed C(sp2)?H Alkoxycarbonylation of Phenethyl- and Benzylamines with Chloroformates as CO Surrogates
Andrade-Sampedro, Paula,Matxain, Jon M.,Correa, Arkaitz
supporting information, p. 5782 - 5789 (2021/03/06)
The site-selective functionalization of C?H bonds within a complex molecule remains a challenging task of capital synthetic importance. Herein, an unprecedented Pd-catalyzed C(sp2)?H alkoxycarbonylation of phenylalanine derivatives and other amines featuring picolinamide as the directing group (DG) is reported. This oxidative coupling is distinguished by its scalability, operational simplicity, and avoids the use of toxic carbon monoxide as the C1 source. Remarkably, the easy cleavage of the DG enables the efficient assembly of isoindolinone compounds. Density Functional Theory calculations support a PdII/PdIV catalytic cycle.
Palladium-Catalyzed Direct C-H Carbonylation of Free Primary Benzylamines: A Synthesis of Benzolactams
Zhang, Chunhui,Ding, Yongzheng,Gao, Yuzhen,Li, Shangda,Li, Gang
supporting information, p. 2595 - 2598 (2018/05/22)
A protocol for palladium-catalyzed C-H carbonylation of readily available free primary benzylamines using NH2 as the chelating group under an atmospheric pressure of CO has been achieved, providing a general, atom- and step-economic approach to
HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS
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Page/Page column 72, (2009/03/07)
The present invention related to novel heterocyclic amide compounds of Formula 1: as disclosed herein or a pharmaceutically accept able salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosedare compositions comprising said compounds, and methods for using said compounds for treating or preventing a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal disease
COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS
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Page/Page column 561, (2010/02/15)
This invention relates to compounds of the Formula (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.