- [(Aminomethyl)aryloxy]acetic acid esters. A new class of high-ceiling diuretics. 3. Variation in the bridge between the aromatic rings to complete mapping of the receptor
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Continued structural evaluation of the [(aminomethyl)aryloxy]acetic ester diuretics has produced a series of compounds in which the functional group that bridges the two aromatic rings has been varied. Diuretic screening of these analogues in rats indicat
- Plattner,Martin,Smital,et al.
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- Diphenyl ether, diphenyl thioether and diphenyl methane phenol mannich bases
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Described are compounds of the formula STR1 wherein R is hydrogen, loweralkyl, aminomethyl or halo; R1 is carboxy, carboxyloweralkyl, aminocarbonyl, hydroxymethyl, anilinomethyl, or aminomethyl; A is oxygen, CH2, Sulfur or a single bond; X is oxygen, CH2, sulfur or sulfoxide; and Y is hydrogen, loweralkyl or halo and may be the same or different, and pharmaceutically acceptable salts thereof. The compounds are effective as diuretic agents.
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