871829-50-4

Basic information

• Product Name: 2-chloro-5-(ethoxymethyl)pyridine
• Synonyms: 2-chloro-5-(ethoxymethyl)pyridine
• CAS NO: 871829-50-4
• Molecular Formula: C8H10ClNO
• Molecular Weight: 172
• Mol File: 871829-50-4.mol

Chemical Properties

• Boiling Point: 236℃
• Flash Point: 96℃
• Appearance: /
• Density: 1.141
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-chloro-5-(ethoxymethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-(ethoxymethyl)pyridine(871829-50-4)
• EPA Substance Registry System: 2-chloro-5-(ethoxymethyl)pyridine(871829-50-4)

Safety Data

• Hazardous Substances Data: 871829-50-4(Hazardous Substances Data)

Usage

Uses

Used in Advanced Organic Synthesis:
2-chloro-5-(ethoxymethyl)pyridine is used as a key intermediate in the synthesis of various complex organic molecules. Its unique structure allows for versatile reactions and transformations, making it a valuable component in the creation of advanced chemical compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-chloro-5-(ethoxymethyl)pyridine is used as a building block for the development of new drugs. Its chemical properties enable it to be incorporated into the structures of potential therapeutic agents, contributing to the discovery and design of novel medications.
Used in Chemical Research:
2-chloro-5-(ethoxymethyl)pyridine is also utilized in academic and industrial research settings as a model compound for studying the properties and reactions of pyridine derivatives. This helps in understanding the broader chemical behavior of similar compounds and can lead to the development of new synthetic methods and applications.

Upstream product

• 70258-18-3 2-chloro-5-(chloromethyl)pyridine 
• 64-17-5 ethanol 

Relevant articles and documents

Inhibitors of Bruton's Tyrosine Kinase

This application discloses 5-phenyl-1H-pyridin-2-one, 6-phenyl-2H-pyridazin-3-one, and 5-Phenyl-1H-pyrazin-2-one derivatives according to generic Formulae I-III: wherein, variables Q, R, X, X′, Y1, Y2, Y2′, Y3, Y4, Y5, m, and n are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-III and at least one carrier, diluent or excipient.

Preparation of substituted 2-chloropyridines

A process for the preparation of a substituted 2-chloropyridine derivatives of the formula STR1 in which R1, R2, R3 and R4 represent hydrogen or various other radicals, which comprises reacting a pyridine-1-oxide of the formula STR2 with an aromatic carbonyl chloride in the presence of an inert organic solvent and in the presence of an acid acceptor at a temperature between about -20° C. and 200° C.

Process for the preparation of substituted 2-chloropyridines

A new process has been found for the preparation of substituted 2-chloropyridine derivatives of the formula (I) STR1 wherein R1 to R4 have the meanings as defined in the description. The new process is characterized in that pyridine 1-oxides of the formula II STR2 are reacted with a chlorine-containing phosphoric acid derivative from the series of the chlorophosphoric esters and chlorophosphoramides in the presence of an inert organic solvent and in the presence of an acid acceptor at temperatures between -20° C. and 200° C., and the resulting product is separated further, if appropriate. Compound (I) is known as an intermediate product for medicaments (cf.DE-A 2,812,585) or for insecticidel nitromethylene derivatives (cf. EP-A 163,855).