- ZINC-SELECTIVE FLUORESCENT PROBES FOR EMISSION-RATIOMETRIC IMAGING
-
A compound according to Formula (I):, wherein Z is: (II).
- -
-
Paragraph 0011; 0117
(2019/01/07)
-
- COMPOUNDS AND METHODS for the inhibition of HDAC
-
Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, Z, L and n are as defined herein, and methods of making and using the same.
- -
-
-
- Discovery of substituted 2,4,4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists
-
Novel imidazoline derivatives were discovered to be potent neuropeptide Y Y5 receptor antagonists. High-throughput screening of Merck sample collections against the human Y5 receptor resulted in the identification of 2,4,4-triphenylimidazoline (1), which had an IC50 of 54 nM. Subsequent optimization led to the identification of several potent derivatives.
- Sato, Nagaaki,Jitsuoka, Makoto,Ishikawa, Shiho,Nagai, Keita,Tsuge, Hiroyasu,Ando, Makoto,Okamoto, Osamu,Iwaasa, Hisashi,Gomori, Akira,Ishihara, Akane,Kanatani, Akio,Fukami, Takehiro
-
scheme or table
p. 1670 - 1674
(2009/11/30)
-
- 4,6-DISUBSTITUTED PYRIMIDINES AND THEIR USE AS PROTEIN KINASE INHIBITORS
-
The invention relates to novel pyrimidine derivatives of Formula (I), which are efficacious inhibitors of protein kinases, in particular of one or more isoforms of the protein kinase B/Akt.
- -
-
Page/Page column 57-58
(2008/06/13)
-