A NOVEL SYNTHESIS OF THE CYCLIC CARBINOLAMIDE MOIETY OF THE MAYTANSINOIDS
The α-diketo-urethane 3 cyclizes to form the cyclic carbinolamide 4 using TMS triflate and 2,6-di-t-butylpyridine.The siloxy group of 4 is readily exchanged in methanol or water to form 6 or 7.Remarkably, 3 does not cyclize spontaneously or on standard acid catalysis.
Petrakis, Konstantinos S.,Fried, Josef
p. 3065 - 3066
(2007/10/02)
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