873075-53-7

Basic information

• Product Name: 3-(2,4-Difluorophenyl)Prop-2-Ynoic Acid
• Synonyms: 3-(2,4-Difluorophenyl)Prop-2-Ynoic Acid;3-(2,4-difluorophenyl)-2-Propynoic acid;3-(2,4-Difluorophenyl)Prop-2-Ynoic Acid(WX610321)
• CAS NO: 873075-53-7
• Molecular Formula: C₉H₄F₂O₂
• Molecular Weight: 182.1236664
• Mol File: 873075-53-7.mol

Chemical Properties

• Boiling Point: 288.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.43±0.1 g/cm3(Predicted)
• PKA: 1.48±0.10(Predicted)
• CAS DataBase Reference: 3-(2,4-Difluorophenyl)Prop-2-Ynoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,4-Difluorophenyl)Prop-2-Ynoic Acid(873075-53-7)
• EPA Substance Registry System: 3-(2,4-Difluorophenyl)Prop-2-Ynoic Acid(873075-53-7)

Safety Data

• Hazardous Substances Data: 873075-53-7(Hazardous Substances Data)

Upstream product

• 2265-93-2 2,4-difluoro-1-iodobenzene 
• 471-25-0 Propiolic acid 

Downstream Products

• 943343-37-1 3-(2,4-difluorophenyl)-N-(2-(pyridine-2-yl)ethyl)propiolamide 

Relevant articles and documents

Substituted 1-propiolylpiperazine compounds, their preparation and use

Substituted 1-propiolylpiperazine compounds corresponding to formula I in which X denotes N or C—R2, and n is an integer from 0 to 8, a method for producing such substituted 1-propiolylpiperazine compounds, pharmaceutical compositions containing such substituted 1-propiolylpiperazine compounds, and the use of such substituted 1-propiolylpiperazine compounds for modulating mGluR5 receptor activity or for treating or inhibiting pain and various other conditions, especially conditions at least partly mediated by the mGluR5 receptor.

SUBSTITUTED 1-PROPIOLYLPIPERAZINES HAVING AN AFFINITY FOR THE MGLUR5 RECEPTOR IN ORDER TO TREAT PAINFUL CONDITIONS

The invention relates to substituted 1-propiolylpiperazines according to formula (I), to a method for the production thereof, medicaments containing said compounds and to the use thereof in the production of medicaments. In formula (I), X represents N or C-R2 and n corresponds to a value between 0-8.