873090-18-7

Basic information

• Product Name: 5-(3-BROMO-PHENYL)-3H-[1,3,4]OXADIAZOL-2-ONE
• Synonyms: 1,3,4-OXADIAZOL-2(3H)-ONE, 5-(3-BROMOPHENYL)-;5-(3-BROMO-PHENYL)-3H-[1,3,4]OXADIAZOL-2-ONE;tert-butyl furan-2-ylcarbamate;5-(3-broMophenyl)-2,3-dihydro-1,3,4-oxadiazol-2-one
• CAS NO: 873090-18-7
• Molecular Formula: C₈H₅BrN₂O₂
• Molecular Weight: 241.044
• Mol File: 873090-18-7.mol

Chemical Properties

• Melting Point: 185.6-186.3 °C
• Appearance: /
• Density: 1.853 g/cm³
• Refractive Index: 1.699
• PKA: 5.76±0.70(Predicted)
• CAS DataBase Reference: 5-(3-BROMO-PHENYL)-3H-[1,3,4]OXADIAZOL-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-BROMO-PHENYL)-3H-[1,3,4]OXADIAZOL-2-ONE(873090-18-7)
• EPA Substance Registry System: 5-(3-BROMO-PHENYL)-3H-[1,3,4]OXADIAZOL-2-ONE(873090-18-7)

Safety Data

• Hazardous Substances Data: 873090-18-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-(3-BROMO-PHENYL)-3H-[1,3,4]OXADIAZOL-2-ONE is used as a pharmaceutical agent for its antimicrobial, antifungal, and anti-inflammatory properties. Its unique structure and potential therapeutic applications make it a valuable compound for the development of new drugs to treat various infections and inflammatory conditions.
Used in Antimicrobial Applications:
5-(3-BROMO-PHENYL)-3H-[1,3,4]OXADIAZOL-2-ONE is used as an antimicrobial agent to combat bacterial infections. Its ability to inhibit the growth of microorganisms makes it a potential candidate for the development of new antibiotics to address the growing issue of antibiotic resistance.
Used in Antifungal Applications:
5-(3-BROMO-PHENYL)-3H-[1,3,4]OXADIAZOL-2-ONE is used as an antifungal agent to treat fungal infections. Its potential to inhibit the growth of fungi makes it a promising compound for the development of new antifungal drugs to address the increasing prevalence of drug-resistant fungal infections.
Used in Anti-inflammatory Applications:
5-(3-BROMO-PHENYL)-3H-[1,3,4]OXADIAZOL-2-ONE is used as an anti-inflammatory agent to reduce inflammation and alleviate symptoms associated with inflammatory conditions. Its potential to modulate inflammatory responses makes it a valuable compound for the development of new therapeutic agents to treat various inflammatory diseases.

InChI:InChI=1/C8H5BrN2O2/c9-6-3-1-2-5(4-6)7-10-11-8(12)13-7/h1-4H,(H,11,12)

Upstream product

• 1422157-64-9 C₁₂H₁₄BrClN₂O₂ 
• 348162-59-4 C₁₂H₁₅BrN₂O₂ 
• 3132-99-8 m-bromobenzoic aldehyde 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 39115-96-3 3-bromo-benzoic acid hydrazide 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 1024613-87-3 1'-[5-(3-bromophenyl)-1,3,4-oxadiazol-2-yl]-1,4'-bipiperidinyl 
• 1024613-88-4 [5-(3-bromophenyl)-1,3,4-oxadiazol-2-yl]-tert-butylamine 
• 1024613-82-8 benzyl[5-(3-bromophenyl)-1,3,4-oxadiazol-2-yl]amine 
• 889117-68-4 C₉H₆N₂O₃ 

Relevant articles and documents

Synthesis of 5-aryl-3H-[1,3,4]oxadiazol-2-ones from N′-(chloro-aryl- methylene)-tert-butylcarbazates using basic alumina as an efficient and recyclable surface under solvent-free condition

The synthesis of biologically important 5-aryl-3H-[1,3,4]oxadiazol-2-ones has been carried out by heating the easily synthesized N′-(chloro-aryl- methylene)-tert-butylcarbazates on basic alumina surface under solvent-free condition. The dual characteristic of basic alumina as a solid support as well as a nucleophile is successfully exploited in these reactions. The method provides special attributions such as reduced reaction times, easier work-up procedures, and good to excellent yields as well as increased purity of products and most importantly environmentally friendly protocols. The basic alumina is easily recovered and utilized for further reactions several times without serious loss of activity.

SYNTHESIS AND CRYSTALLINE FORMS OF CB-1 ANTAGONIST/INVERSE AGONIST

The present invention relates to a process for producing crystalline 3-[(1S)-1-(1-{(S)-(4-chlorophenyl)[3-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl]methyl} azetidin-3-yl)-2-fluoro-2-methylpropyl]-5-fluorobenzonitrile, and novel salts, solvates, hydrates and polymorphs thereof.

Efficient phosphonium-mediated synthesis of 2-amino-1,3,4-oxadiazoles

We present an efficient, room temperature procedure for the preparation of 2-amino-1,3,4-oxadiazoles. Oxadiazol-2-ones can be activated for SnAr substitution using phosphonium reagents (e.g., BOP). This approach provides convenient access to N,

Parallel synthesis of a library of acylsemicarbazides using a solution-phase one-pot method and their evaluation as crop-protection agents

A solution-phase one-pot synthesis of a 40-member acylsemicarbazide library is outlined. The acylsemicarbazides were prepared by reacting various hydrazides with N,N′-carbonyldiimidazole (CDI) to generate 1,3,4-oxadiazole-2-one intermediates, which were t