87414-22-0Relevant articles and documents
5-p-Benzoquinonyl-2'-deoxyuridine-5'-phosphate: A possible mechanism-based inhibitor of thymidylate synthetase
Maggiora,Chang,Hasson,Bigge,Mertes
, p. 1028 - 1036 (2007/10/02)
The title compound (91), designed as a suicide inhibitor of thymidylate synthetase, can be prepared by silver(II) oxide oxidative demethylation of the corresponding dimethoxyphenyl derivative. Compound 1 shows time-dependent inactivation of thymidylate sy