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CAS

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874459-98-0

3-(2-Pyridylcarbamoyl)benzeneboronic acid, 97% is a chemical compound that serves as an impurity in Acalabrutinib (A115605), an experimental anti-cancer drug and a selective Bruton's tyrosine kinase (BTK) inhibitor. This kinase plays a crucial role in transmitting signals from the B-cell receptor (BCR), and any genetic BTK mutation can lead to B-cell immunodeficiency.

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  • 874459-98-0 Structure

  • Basic information

    1. Product Name: 3-(2-PyridylcarbaMoyl)benzeneboronic acid, 97%
    2. Synonyms: 3-(2-PyridylcarbaMoyl)benzeneboronic acid, 97%
    3. CAS NO:874459-98-0
    4. Molecular Formula: C12H11BN2O3
    5. Molecular Weight: 242.03834
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 874459-98-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.33±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 7.87±0.10(Predicted)
    10. CAS DataBase Reference: 3-(2-PyridylcarbaMoyl)benzeneboronic acid, 97%(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3-(2-PyridylcarbaMoyl)benzeneboronic acid, 97%(874459-98-0)
    12. EPA Substance Registry System: 3-(2-PyridylcarbaMoyl)benzeneboronic acid, 97%(874459-98-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 874459-98-0(Hazardous Substances Data)

874459-98-0 Usage

Uses

Used in Pharmaceutical Industry:
3-(2-Pyridylcarbamoyl)benzeneboronic acid, 97% is used as an impurity in the development and production of Acalabrutinib, a selective BTK inhibitor. 3-(2-PyridylcarbaMoyl)benzeneboronic acid, 97% has shown great promise for the treatment of chronic lymphocytic leukemia (CLL) by targeting B-cell signaling pathways.

Check Digit Verification of cas no

The CAS Registry Mumber 874459-98-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,4,5 and 9 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 874459-98:
(8*8)+(7*7)+(6*4)+(5*4)+(4*5)+(3*9)+(2*9)+(1*8)=230
230 % 10 = 0
So 874459-98-0 is a valid CAS Registry Number.

874459-98-0Upstream product

874459-98-0Downstream Products

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