874819-71-3

Basic information

• Product Name: N-(2-Nitrophenyl)phosphoric TriaMide
• Synonyms: (2-Nitrophenyl)phosphoric TriaMide;N-(2-Nitrophenyl)phosphoric TriaMide;N-diaminophosphoryl-2-nitroaniline
• CAS NO: 874819-71-3
• Molecular Formula: C6H9N4O3P
• Molecular Weight: 216.134421
• Product Categories: Amines;Aromatics;Phosphorylating and Phosphitylating Agents
• Mol File: 874819-71-3.mol

Chemical Properties

• Boiling Point: 416.5±47.0 °C(Predicted)
• Appearance: /
• Density: 1.592±0.06 g/cm3(Predicted)
• Vapor Pressure: 0Pa at 20℃
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.07±0.70(Predicted)
• Water Solubility: 1.394g/L at 20℃
• CAS DataBase Reference: N-(2-Nitrophenyl)phosphoric TriaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Nitrophenyl)phosphoric TriaMide(874819-71-3)
• EPA Substance Registry System: N-(2-Nitrophenyl)phosphoric TriaMide(874819-71-3)

Safety Data

• Hazardous Substances Data: 874819-71-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-(2-nitrophenyl)phosphoric triamide is used as a precursor for the synthesis of N-phenylphosphoric acid triamide derivatives, which are employed as agents for regulating or inhibiting enzymatic urea hydrolysis. This application is particularly relevant in the development of drugs targeting conditions related to urea metabolism and balance.
Used in Chemical Research:
As a yellow solid with unique chemical properties, N-(2-nitrophenyl)phosphoric triamide can be utilized in chemical research for the investigation of its reactivity, stability, and potential interactions with other compounds. This can lead to the discovery of new applications and uses in various industries.

Flammability and Explosibility

Nonflammable

Upstream product

• 100868-50-6 (2-Nitro-anilino)-phosphorsaeure-dichlorid 

Relevant articles and documents

Design, synthesis, and biological evaluation of phosphoramide derivatives as urease inhibitors

The design, synthesis, and biological evaluation of phosphoramide derivatives as urease inhibitors to reduce the loss of ammonia has been carried out. Forty phosphorus derivatives were synthesized and their inhibitory activities evaluated against that of jack bean urease. In addition, in vivo assays have been carried out. All of the compounds were characterized by IR, 1H NMR, MS, and elemental microanalysis. In some cases, detailed molecular modeling studies were carried out, and these highlighted the interaction between the enzyme active center and the compounds and also the characteristics related to their activity as urease inhibitors. According to the IC50 values for in vitro inhibitory activity, 12 compounds showed values below 1 μM and 8 of them represent improvements of activity in comparison to the commercial urease inhibitor N-n-butylthiophosphorictriamide (NBPT) (100 nM) (AGROTAIN). On the basis of the activity results and the conclusions of the molecular modeling study, a structural model for new potential inhibitors has been defined.

N-PHENYLPHOSPHORIC ACID TRIAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS AGENTS FOR REGULATING OR INHIBITING ENZYMATIC UREA HYDROLYSIS

The invention relates to N-phenylphosphonic acid triamides of general formula (I), to a method for the production thereof and to their use as agents for regulating or inhibiting enzymatic urea hydrolysis. In formula (I), X represents oxygen or sulfur; Rs