- Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation
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A series of small molecule orally bioavailable ghrelin receptor agonists have been identified through systematic optimisation of a high throughput screening hit. Crown Copyright
- Witherington, Jason,Abberley, Lee,Briggs, Michael A.,Collis, Katharine,Dean, David K.,Gaiba, Alessandra,King, N. Paul,Kraus, Helmut,Shuker, Nicola,Steadman, Jon G.A.,Takle, Andrew K.,Sanger, Gareth,Wadsworth, Graham,Butler, Sharon,McKay, Fiona,Muir, Alison,Winborn, Kim,Heightman, Tom D.
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- PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS
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The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ra, Rb, Rc, Rd, Re, Rf and Y are as defined in the specification. The compounds are partial or full agonists at the growth hormone secretagogue (GHS) receptors . Pharmaceutical compositions comprising the compounds, methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.
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Page/Page column 42; 116
(2010/02/15)
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