PYRIDAZINES CONDENSED WITH A HETERO RING, II. PYRIDO AMINOPYRIDAZINES, I. SEPARATION AND STRUCTURE DETERMINATION OF THE ISOMERIC MONOCHLORO COMPOUNDS OBTAINED BY HYDROLYSIS OF 1,4-DICHLOROPYRIDOPYRIDAZINE
The separation of the mixture of isomers 2 and 3, obtained by hydrolysis of 1,4-dichloropyrido pyridazine, was accomplished and the structures of the isomers (2: 1-Cl; 3:4-Cl) were verified by synthesis.Aminolysis of 2 and 3 yielded the hydroxy-ethylamino derivatives 4 and 5; a mixture of these compounds can also be synthesized from 2-tosyloxyethylcinchomeronic imide (20 -> 4, 5) in a good yield (84percent).
Koermendy, K.,Kovacs, T.,Ruff, F.,Koevesdi, I.
p. 487 - 500
(2007/10/02)
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