- Electrochemical Reductive Smiles Rearrangement for C-N Bond Formation
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A conceptually new and synthetically valuable radical Smiles rearrangement reaction is reported under undivided electrolytic conditions. This protocol employs an entirely new strategy for the electrochemical radical Smiles rearrangement. Remarkably, an amidyl radical generated from the cleavage of the N-O bond under reductive electrolytic conditions plays a crucial role in this transformation. Various hydroxylamine derivatives bearing different substituents are suitable in this electrochemical transformation, furnishing the corresponding amides in up to 86% yield.
- Chang, Xihao,Zhang, Qinglin,Guo, Chang
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supporting information
p. 10 - 13
(2019/01/04)
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- Anthraquinone general formula compound and application thereof
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The invention discloses an anthraquinone general formula compound and application thereof. The general formula compound is shown in a formula in the specification, in the formula, Y represents an oxygen atom or a sulfur atom, X1 to X8 represent C, CR or N
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Paragraph 0046; 0048-0050
(2019/11/14)
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- Anthraquinone organic electroluminescent material and application thereof
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The invention discloses an anthraquinone organic electroluminescent material and application thereof. A general formula compound is shown in a formula (1) in the specification, and in the formula (1),Z is selected from O or S; X1-X8 are independently selected from CR1 or N, wherein R1 is selected from a structure shown in a formula (2) in the specification, or selected from hydrogen, alkyl, arylor heterocyclic aryl, adjacent R1 groups can form a ring, and at least one of R1 groups is selected from the structure (2) shown in the formula (2); in the formula (2), Y1-Y8 are independently selected from CR2 or N, and at least one of the Y1-Y8 is selected from N; R2 is selected from hydrogen, alkyl, aryl or heterocyclic aryl, and adjacent R2 groups can form a ring; L is selected from single bonds, arylidene or heterocyclic arylidene; and when two or more R1 groups are selected from the formula (2), the selected L groups in the formula (2) are not single bonds at the same time. The compoundshows excellent device performance and stability when serving as the light-emitting material in an organic light-emitting device (OLED), and meanwhile the OLED adopting the general formula compound iswithin the scope of right protection.
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Paragraph 0058; 0060-0062
(2019/11/14)
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- High-efficiency long-service life organic room-temperature phosphorescence material and preparation method thereof
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The invention provides an alkoxy, benzyloxy or bromine substituted xanthone derivative and a preparation method thereof. The xanthone derivative is simple in preparation method, has a phosphorescencepeak on a long wavelength peak and is long in phosphorescence service life and high in light emission efficiency. The preparation method of the xanthone derivative comprises the following preparationsteps: 1, putting phenol, potassium carbonate, DMF (Dimethyl Formamide) and methylbenzene into a reaction container, backflowing for 3-5 hours in a nitrogen environment, and carrying out dehydration treatment till the system has no water generation; removing the methylbenzene, recovering to the room temperature, adding 4-bromine-2-fluorobenzonitrile, backflowing for 3-5 hours in the nitrogen environment, after the reaction is completed, diluting the solution with 100mL of methylbenzene, filtering, washing with water, drying so as to obtain a crude product of a crystal, and purifying with a spectrum column so as to obtain an intermediate as shown in the specification; 2, mixing the intermediate obtained in the step 1 with water and sulfuric acid, heating to 150-200 DEG C in the nitrogen environment, stirring, and backflowing for 10-15 hours; after the reaction is completed, cooling to the room temperature, diluting with water, extracting by using trichloromethane and a saturated sodiumchloride solution, combining organic phases, drying, filtering, carrying out vacuum distillation so as to remove the solvent and obtain a crude product of a crystal, and purifying with a spectrum column, so as to obtain an intermediate as shown in the specification.
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Paragraph 0053; 0054
(2019/01/08)
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- Efficient Aryl Migration from an Aryl Ether to a Carboxylic Acid Group To Form an Ester by Visible-Light Photoredox Catalysis
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We have developed a highly efficient aryl migration from an aryl ether to a carboxylic acid group through retro-Smiles rearrangement by visible-light photoredox catalysis at ambient temperature. Transition metals and a stoichiometric oxidant and base are avoided in the transformation. Inspired by the high efficiency of this transformation and the fundamental importance of C?O bond cleavage, we developed a novel approach to the C?O cleavage of a biaryl ether to form two phenolic compounds, as demonstrated by a one-pot, two-step gram-scale reaction under mild conditions. The aryl migration exhibits broad scope and can be applied to the synthesis of pharmaceutical compounds, such as guacetisal. Primary mechanistic studies indicate that the catalytic cycle occurs by a reductive quenching pathway.
- Wang, Shao-Feng,Cao, Xiao-Ping,Li, Yang
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p. 13809 - 13813
(2017/10/24)
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- Light emitting material, delayed fluorescent emitter, organic light emitting device, and compound
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A compound represented by the following general formula is useful as a light emitting material. X represents an oxygen atom or a sulfur atom. R1 to R8 represent a hydrogen atom or a substituent, provided that at least one of R1
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Page/Page column 85-86
(2017/07/06)
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- TRICYCLIC DELTA- OPIOID MODULATORS
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The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators, of formula (I). Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
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Page/Page column 85
(2010/11/26)
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- Tricyclic delta-opioid modulators
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The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using com
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Page/Page column 23
(2008/06/13)
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