- A novel artificial superoxide dismutase: Non-covalent conjugation of albumin with a MnIII salophen type complex
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The approach of non-covalent conjugation has recently been used and a number of metal complexes have been encaged in a protein scaffold to form functional metallo proteins. Here we investigate a novel artificial superoxide dismutase enzyme based on the non-covalent conjugation of bovine serum albumin and the manganese(III) complex of N,N′-bis(salicylidene)-3,4- diaminobenzoic acid. We report the intriguing ability of the albumin environment to increase the SOD activity of the inorganic complex. We also determined the binding constant with BSA by CD spectroscopy.
- Oliveri, Valentina,Vecchio, Graziella
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- Molecular Solar Thermal Batteries through Combination of Magnetic Nanoparticle Catalysts and Tailored Norbornadiene Photoswitches
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Cobalt catalysts are immobilized on the surface of iron oxide nanoparticles for the preparation of highly active quasi-homogeneous catalysts toward an efficient release of photochemically stored energy in norbornadiene-based photoswitches. The facile sepa
- Lorenz, Patrick,Luchs, Tobias,Hirsch, Andreas
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supporting information
p. 4993 - 5002
(2021/02/26)
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- New Zn(II) complexes of substituted bis(Salicylidene)phenyl-1,2-diamino based organic ligands: Synthesis, photoluminescence, applications in forensic fingerprint and dye sensitized solar cells
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New azomethine-Zn(II) complexes of bis(salicylidene)phenyl-1,2-diamino organic ligand derivatives were synthesized by the reaction of salicylaldehyde, substituted phenyl-1,2-diamine with zinc acetate. The synthesized complexes were characterized by FTIR,1H NMR and EDS. Their photophysical and electrochemical properties were studied and their applicability for dye-sensitized solar cells (DSSCs) and forensic finger print developments have been demonstrated. Photoluminescence studies revealed that the emission peaks of the complexes in solution state appeared at 372-406 nm and emitted blue light. Latent fingerprint detection study indicated that the powder compounds show good adhesion and finger ridge details without back ground staining. Based on these results, it was ascertained that these Zn(II) complexes can serve as a suitable non-dopant blue light emitting compound for flat panel display applications and applied to detect fingerprints on all types of smooth surfaces.
- Srinivas,Sulochana,Kumar, G.R. Yogesh,Mahadevan,Naik, H.S. Bhojya
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p. 945 - 951
(2020/03/24)
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- Synthesis, characterization, photoluminescence property of Al(III) Schiff base complexes and their applications in forensic fingerprint and dye sensitized solar cells
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Aluminium(III)-Schiff base complexes of bis(salicylidene)phenyl-1,2-diamino organic ligand derivatives were synthesized by condensation reaction with salicylaldehyde, substituted phenyl-1,2-diamine with aluminum trichloride and characterized by 1H NMR, FTIR, EDS and ICP-AAS. Photophysical properties like photoluminescence (PL) and IV characteristics were studied for the dye-sensitized solar cells (DSSCs) performance. The latent forensic finger print developments have also been demonstrated from the synthesized complexes. Photoluminescence studies revealed that emission peaks of the complexes in solution state appeared at 418- 572 nm and emitted blue and pale-yellow light. Latent fingerprint detection study indicated that the powder compounds show a good adhesion and finger ridge details without back ground staining. Based on these results, these Al(III) complexes can serve as a suitable non-dopant blue light as well as pale yellow light emitting compound for flat panel display applications and applied to detect latent fingerprints on variable substrates.
- Srinivas,Sulochana,Ramesh,Rajegowda,Mahadevan,Neelagund, Shivayogeeswara
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p. 1427 - 1432
(2020/06/10)
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- Amide and ester derivatives of chlorido[4-carboxy-1,2-disalicylideneaminobenzene]iron(iii) as necroptosis and ferroptosis inducers
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In continuation of the structure-activity study about 4-substituted chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(iii) complexes as necroptosis and ferroptosis inducers, we introduced a 4-COOH group at the 1,2-phenylenediamine moiety of the lead
- Baecker, Daniel,Gust, Ronald,H?rschl?ger, Carina,Kircher, Brigitte,Ma, Benjamin N.,Sagasser, Jessica,Schultz, Lukas,Steiner, Lucy,Weinreich, Maria
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p. 6842 - 6853
(2020/06/08)
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- Bioconjugates of Co(III) complexes with Schiff base ligands and cell penetrating peptides: Solid phase synthesis, characterization and antiproliferative activity
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In this work we synthesized a chelating Schiff base by a single condensation of salicylaldehyde with 3,4-diamino benzoic acid (1). This ligand was used further for complexation to CoCl2·6H2O under nitrogen. In the next step, three six-coordinate Co(III) complexes were synthesized by coordinating this complex with imidazole (2), 2-methyimidazole (3) and N-Boc-L-histidine methyl ester (4) (Boc: tert.-butoxycarbonyl) in axial positions with simultaneous oxidation of Co(II) to Co(III) under ambient environment. All Co(III) complexes were characterized by multinuclear NMR spectroscopy (1H, 13C and 59Co NMR), FT-IR, mass spectrometry and HPLC. The Co(III) complexes were conjugated to three different cell penetrating peptides: FFFF (P1), RRRRRRRRRGAL (P2) and FFFFRRRRRRRRRGAL (P3). Standard solid-phase peptide chemistry was used for the synthesis of cell penetrating peptides. Coupling of N-terminal peptides with the cobalt complexes, possessing a carboxylic group on the tetradentate Schiff base ligand, afforded Co(III)-peptide bioconjugates, which were purified by semi-preparative HPLC and characterized by analytical HPLC and mass spectrometry. The antiproliferative activity of the synthesized compounds was studied against different human tumour cell lines: lung cancer A549, liver cancer HepG2 and normal human fibroblasts GM5657T, in comparison with the activity of cisplatin as a reference drug. The bioconjugate 21 containing the Co complex 4 and the combined phenylalanine and polyarginine cell penetrating sequence P3 shows better activity against the liver cancer line HepG2 than the parent Co(III) complex 4.
- Metzler-Nolte, Nils,?mi?owicz, Dariusz
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- Fe3O4@SiO2@Im[Cl]Mn(III)-complex as a highly efficient magnetically recoverable nanocatalyst for selective oxidation of alcohol to imine and oxime
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An efficient and environmentally friendly oxidation process for the one-pot preparation of oxime, imine and carbonyl compounds through alcohol oxidation in the presence of H2O2 and/or O2 have been developed by a melamine-Mn(III) Schiff base complex supported on Fe3O4@SiO2–Cl nanoparticles, named as Fe3O4@SiO2@Im[Cl]Mn(III)-complex nanocomposite, at room temperature. Direct oxidation of alcohol to carboxylic acid was performed using the catalyst in the presence of molecular O2 at room temperature in a different approach. The oxidation products were obtained with excellent yields and high TOFs. The properties of the catalyst were characterized by Fourier transform infrared spectroscopy (FTIR), elemental analysis (C, H, N), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), dynamic light scattering (DLS), energy dispersive X-ray analysis (EDX), X-ray photoelectron spectroscopy (XPS), inductive coupled plasma (ICP), cyclic voltammetry (CV), nuclear magnetic resonance (1H & 13C NMR), vibration sample magnetometer (VSM), Brunauer– Emmett–Teller (BET) and differential pulse voltammetry (DPV) analyses. The mechanism of the oxidation processes was investigated for the both H2O2 and O2 oxidants. The role of the imidazolium moiety in the catalyst as a secondary functionality was investigated. Chemoselectivity behavior of the catalyst was studied by some combinations. The catalyst could be recycled from the reaction mixture by a simple external magnet and reused for several times without any considerable reactivity loss.
- Kazemnejadi, Milad,Alavi, Seyyedeh Ameneh,Rezazadeh, Zinat,Nasseri, Mohammad Ali,Allahresani, Ali,Esmaeilpour, Mohsen
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p. 230 - 249
(2019/03/28)
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- Design, synthesis and biological evaluation of cobalt(II)-Schiff base complexes as ATP-noncompetitive MEK1 inhibitors
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In this report, we designed and synthesized a series of cobalt(II)-Schiff base complexes (CoSBC) with competent MEK1 (mitogen-activated protein kinase kinase?1) inhibitory activity. Based on our previous report, the CoSBC exhibited high binding affinity with MEK1 protein. To further explore metal complexes as MEK1 inhibitors, a series of transition metals and ligands were employed to build a library of various metal Schiff base complexes. The MEK inhibition assays revealed that only CoSBC exhibited obvious inhibitory activity, complex 2b showed the best inhibition both in BRaf (B-rapidly accelerated fibrosarcoma)/MEK1 and MEK1/ERK2 (extracellular signal-regulated kinases-2) cascading (IC50 is 1.988 ± 0.14 μM and 1.589 ± 0.054 μM respectively). In addition, homogeneous time-resolved fluorescence test method was used to prove that CoSBC as ATP-noncompetitive MEK1 inhibitor. MEK kinase selectivity assay indicated that CoSBC can selectively inhibit MEK1/2 kinases rather than other MAPKs (mitogen-activated protein kinases) family kinases. Moreover, the interaction mode of 2b with MEK1 protein has been demonstrated by computer aided drug design.
- Li, Hongyue,Xi, Dandan,Niu, Yan,Wang, Chao,Xu, Fengrong,Liang, Lei,Xu, Ping
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p. 174 - 181
(2019/04/08)
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- Assembly-enhanced triplet-triplet annihilation upconversion in the aggregation formed by Schiff-base Pt(II) complex grafting-permethyl-β-CD and 9, 10-diphenylanthracence dimer
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Water-soluble triplet sensitizer with permethyl-β-cyclodextrin (PMCD) grafting on a Schiff-base Pt(II) complex (Pt-2), in which PMCD unit serves as a host for binding the acceptors and the Schiff-base Pt(II) complex serves as a triplet sensitizer, was syn
- Lai, Hongxia,Zhao, Ting,Deng, Yurong,Fan, Chunyin,Wu, Wanhua,Yang, Cheng
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supporting information
p. 1979 - 1983
(2019/10/02)
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- Effects of temperature and host concentration on the supramolecular enantiodifferentiating [4 + 4] photodimerization of 2-anthracenecarboxylate through triplet-triplet annihilation catalyzed by Pt-modified cyclodextrins
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Visible-light-driven photocatalytic supramolecular enantiodifferentiating dimerization of 2-anthracenecarboxylic acid (AC) through triplet-triplet annihilation (TTA), mediated by the Schiff base Pt(II) complex (Pt-1, Pt-2, and Pt-3) was studied. The host concentration and the temperature effects on the stereoselectivity were comprehensively investigated. Increasing the concentration of sensitizers/hosts significantly enhanced the conversion of the photoreaction but led to reduced enantioselectivities of the chiral photodimers 2 and 3 when the photoreaction was triggered by a 532 nm laser, which was in contrast with the results obtained by direct irradiation of AC with a 365 nm light-emitting diode (LED) lamp, due to the aggregation of the sensitizer/host in water. The cyclization of AC through triplet-triplet annihilation displayed significant temperature dependency when Pt-3 was employed as the sensitizer/host. Increasing the temperature from 0 ?C to 30 ?C with 5% equiv. of Pt-3 led to a great increase of the ee of 2 from 2.1% to 31.6%. However, hardly any temperature dependency was observed when the photodimerization was mediated by other sensitizers and/or hosts, or the photoreaction was triggered directly with a 365 nm LED lamp.
- Rao, Ming,Wu, Wanhua,Yang, Cheng
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supporting information
(2019/05/02)
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- Photocatalytic Supramolecular Enantiodifferentiating Dimerization of 2-Anthracenecarboxylic Acid through Triplet-Triplet Annihilation
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Visible-light-driven enantiodifferentiating photodimerization of 2-anthracenecarboxylic acid (AC) sensitized by Schiff base Pt(II) complex-grafted γ-cyclodextrins leads the first triplet-triplet annihilation-based catalytic photochirogenesis. The syn-head
- Rao, Ming,Kanagaraj, Kuppusamy,Fan, Chunying,Ji, Jiecheng,Xiao, Chao,Wei, Xueqin,Wu, Wanhua,Yang, Cheng
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supporting information
p. 1680 - 1683
(2018/03/23)
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- Determination of trace uranium by resonance fluorescence method coupled with photo-catalytic technology and dual cloud point extraction
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In this paper, two kinds of salophens (Sal) with different solubilities, Sal1 and Sal2, have been respectively synthesized, and they all can combine with uranyl to form stable complexes: [UO2 2?+-Sal1] and [UO2 2?+/s
- Li, Jiekang,Li, Guirong,Han, Qian
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p. 208 - 215
(2016/07/11)
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- Discovery of a potent and highly specific β2proteasome inhibitor from a library of copper complexes
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We reported the synthesis, characterization and biological activity of several copper(II) Schiff base complexes, which exhibit high proteasome inhibitory activities with particular selectivity of β2subunit. Structure–activity relationships info
- Zhou, Tongliang,Cai, Yuanbo,Liang, Lei,Yang, Lingfei,Xu, Fengrong,Niu, Yan,Wang, Chao,Zhang, Jun-Long,Xu, Ping
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p. 5780 - 5784
(2016/11/25)
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- New 3,4-diaminobenzoic acid Schiff base compounds and their complexes: Synthesis, characterization and thermodynamics
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Some new tetradentate Schiff base ligands (H3L) were prepared via condensation of 3,4-diaminobenzoic acid with 2-hydroxybenzaldehyde derivatives, such as 3,4-bis((E)-2,4-dihydroxybenzylideneamino)benzoic acid (H3L1), 3,4-b
- Mohammadi, Khosro,Niad, Mahmood,Jafari, Tahereh
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p. 179 - 185
(2014/01/06)
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- Synthesis, spectral, thermal and thermodynamic studies of oxovanadium(IV) complexes of Schiff bases derived from 3,4-diaminobenzoic acid with salicylaldehyde derivatives
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Synthesis and evaluation of three new oxovanadium(IV) complexes, formed by the interaction of vanadyl acetylacetonate and the Schiff bases: 3,4-bis((E)-2-hydroxybenzylideneamino)benzoic acid (L1), 3,4-bis-((E)-2-hydroxy-3-methoxybenzylideneamin
- Mohammadi, Khosro,Niad, Mahmood,Irandoost, Amene
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supporting information
p. 145 - 150
(2013/04/24)
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- New phosphorescent platinum(ii) Schiff base complexes for PHOLED applications
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Some new symmetric and asymmetric platinum(ii) Schiff base complexes with bulky substituents such as tert-butyl and triphenylamino groups have been synthesized which effectively reduced the aggregation or excimer formation. Using selected complexes as phosphorescent emitting materials, yellow light-emitting devices were fabricated with improved efficiency compared with the previously reported analogues. In addition, the phosphorescent white organic light-emitting device (WOLED) was fabricated using a single emissive layer composed of yellow- and blue-emitting materials. The Royal Society of Chemistry 2012.
- Zhang, Jie,Zhao, Fangchao,Zhu, Xunjin,Wong, Wai-Kwok,Ma, Dongge,Wong, Wai-Yeung
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experimental part
p. 16448 - 16457
(2012/08/28)
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- APOPTOTIC AND ANTI-TUMOR ACTIVITIES OF METALLO-SALENS
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The present invention describes the synthesis and biochemical activities of metallo-salen compounds and their derivatives. The Mn(III)-salen and Fe(III)-salen derivatives of the present invention are potential anti-tumor agents, that affect cell viability, induce strong apoptotic activity, cause nuclear condensation, fragmentation, and ultimately death in breast cancer cells MCF-7.
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Page/Page column 8
(2010/01/31)
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