Synthesis of 2-alkyl-3-hydroxy-4-pyridinone-ribonucleosides, potential oral iron chelators
Several ribonucleosides, named 2-alkyl-3-hydroxy-1-(β-D-ribofuranosyl or pyranosyl)-4-pyridinones, were synthesized in good yield. The method provides a useful means to obtain α-ketohydroxypyridin derivatives with different sugar moieties that, if used as
Liu,Bruenger,Barrios,Miller
p. 1901 - 1904
(2007/10/02)
Synthesis of 3-Hydroxy-2- and 4-pyridone Nucleosides as Potential Antitumor Agents
The ribo- and arabinofuranosyl nucleosides of antitumor active 2- and 4-pyridones 1a and 2a were prepared by direct condensation of the silylated bases with either 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose (4a) or 2,3,5-tri-O-benzyl-1-p-nitrobenzoyl-D
Mao, David T.,Driscoll, John S.,Marquez, Victor E.
p. 160 - 164
(2007/10/02)
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