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CAS

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876162-07-1

Carbamic acid, [(3R)-1-[(3-nitrophenyl)methyl]-3-pyrrolidinyl]-, 1,1-dimethylethyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 876162-07-1 Structure

  • Basic information

    1. Product Name: Carbamic acid, [(3R)-1-[(3-nitrophenyl)methyl]-3-pyrrolidinyl]-, 1,1-dimethylethyl ester
    2. Synonyms:
    3. CAS NO:876162-07-1
    4. Molecular Formula: C16H23N3O4
    5. Molecular Weight: 321.376
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 876162-07-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Carbamic acid, [(3R)-1-[(3-nitrophenyl)methyl]-3-pyrrolidinyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: Carbamic acid, [(3R)-1-[(3-nitrophenyl)methyl]-3-pyrrolidinyl]-, 1,1-dimethylethyl ester(876162-07-1)
    11. EPA Substance Registry System: Carbamic acid, [(3R)-1-[(3-nitrophenyl)methyl]-3-pyrrolidinyl]-, 1,1-dimethylethyl ester(876162-07-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 876162-07-1(Hazardous Substances Data)

876162-07-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 876162-07-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,6,1,6 and 2 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 876162-07:
(8*8)+(7*7)+(6*6)+(5*1)+(4*6)+(3*2)+(2*0)+(1*7)=191
191 % 10 = 1
So 876162-07-1 is a valid CAS Registry Number.

876162-07-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (3R)-(+)-[1-(3-nitrobenzyl)-3-pyrrolidyl]carbamic acid tert-butyl ester

1.2 Other means of identification

Product number -
Other names [1-(3-nitro-benzyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:876162-07-1 SDS

876162-07-1Relevant articles and documents

Design and synthesis of rho kinase inhibitors (III)

Iwakubo, Masayuki,Takami, Atsuya,Okada, Yuji,Kawata, Takehisa,Tagami, Yoshimichi,Sato, Motoko,Sugiyama, Terumi,Fukushima, Kayoko,Taya, Shinichiro,Amano, Mutsuki,Kaibuchi, Kozo,Iijima, Hiroshi

, p. 1022 - 1033 (2007)

The structure-activity relationship of Rho kinase inhibitors bearing an isoquinoline scaffold was studied. N-(1-Benzyl-3-pyrrolidyl)-N-(5-isoquinolyl)amine analogues were optimized with respect to their inhibitory potencies for the enzyme and for chemotaxis. The potent analogues were further evaluated by an ex vivo test in which the selected compounds were orally administered to rats, and the Rho kinase inhibitory potency observed in the rat serum was evaluated 3 h after the administration. Compound 23g showed a high level of Rho kinase inhibitory activity in the rat serum and was stable in an in vitro metabolic test using a microsomal cytochrome preparation. The (R)-isomer of 23g displayed a higher level of inhibitory potency than the (S)-isomer in a cell-free kinase assay and in the cell migration assay (IC50ENZ = 25 nM and IC50MCP = 1 μ M). The (R)-isomer successfully inhibited the phosphorylation of MBS (myosin-binding subunit) in cells.

ISOQUINOLINE DERIVATIVES HAVING KINASAE INHIBITORY ACTIVITY AND DRUGS CONTAINING THE SAME

-

Page/Page column 28-29, (2008/06/13)

An objective of the present invention is to provide compounds having Rho kinase inhibitory activity and useful for the treatment of diseases mediated by Rho kinase. The compounds according to the present invention are those represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: wherein Q represents phenyl, pyridyl, pyrrolyl, thienyl, or furyl; these groups are optionally substituted by one or two halogens or alkyl, nitro, or amino groups; and p is 2 or 3.

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