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876343-86-1

1(2H)-Pyridinecarboxylic acid, 4-(5-broMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-, 1,1-diMethylethyl ester, also known as BMS-536924, is a carboxylic acid ester compound with potential applications in the pharmaceutical industry. It functions as a selective inhibitor of type I insulin-like growth factor receptor (IGF1R) and insulin receptor (IR), playing a crucial role in regulating cell growth, proliferation, and survival.

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  • 2-Methyl-2-propanyl 4-(5-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridin- 2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

    Cas No: 876343-86-1

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  • 876343-86-1 Structure

  • Basic information

    1. Product Name: 1(2H)-Pyridinecarboxylic acid, 4-(5-broMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-, 1,1-diMethylethyl ester
    2. Synonyms: 1(2H)-Pyridinecarboxylic acid, 4-(5-broMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-, 1,1-diMethylethyl ester;tert-butyl 4-(5-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate;UAJAJTDEJFDKKW-UHFFFAOYSA-N
    3. CAS NO:876343-86-1
    4. Molecular Formula: C17H19BrClN3O2
    5. Molecular Weight: 412.70866
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 876343-86-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1(2H)-Pyridinecarboxylic acid, 4-(5-broMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-, 1,1-diMethylethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1(2H)-Pyridinecarboxylic acid, 4-(5-broMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-, 1,1-diMethylethyl ester(876343-86-1)
    11. EPA Substance Registry System: 1(2H)-Pyridinecarboxylic acid, 4-(5-broMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-, 1,1-diMethylethyl ester(876343-86-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 876343-86-1(Hazardous Substances Data)

876343-86-1 Usage

Uses

Used in Pharmaceutical Industry:
1(2H)-Pyridinecarboxylic acid, 4-(5-broMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-, 1,1-diMethylethyl ester is used as a potential therapeutic agent for the treatment of various types of cancers. Its application is based on its ability to selectively block the activation and subsequent signaling pathways of IGF1R, which is involved in the regulation of cell growth, proliferation, and survival. Preclinical studies have shown promising anti-tumor activity, making BMS-536924 a potential candidate for further development as a targeted therapy for cancer treatment.

Check Digit Verification of cas no

The CAS Registry Mumber 876343-86-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,6,3,4 and 3 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 876343-86:
(8*8)+(7*7)+(6*6)+(5*3)+(4*4)+(3*3)+(2*8)+(1*6)=211
211 % 10 = 1
So 876343-86-1 is a valid CAS Registry Number.

876343-86-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Methyl-2-propanyl 4-(5-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridin- 2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

1.2 Other means of identification

Product number -
Other names 4-(5-bromo4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:876343-86-1 SDS

876343-86-1Downstream Products

876343-86-1Relevant articles and documents

Pyrrolopyridine kinase inhibiting compounds

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Page/Page column 78, (2010/11/27)

Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least one of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Met, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.

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