876690-37-8Relevant articles and documents
Synthesis of elaborate benzofuran‐2‐carboxamide derivatives through a combination of 8-aminoquinoline directed C–H arylation and transamidation chemistry
Holm, Linus Johansson,Oschmann, Michael,Pourghasemi‐Lati, Monireh,Verho, Oscar
supporting information, (2020/01/28)
Herein, we present a short and highly modular synthetic route that involves 8-aminoquinoline directed C–H arylation and transamidation chemistry, and which enables access to a wide range of elaborate benzofuran‐2‐carboxamides. For the directed C–H arylation reactions, Pd catalysis was used to install a wide range of aryl and heteroaryl substituents at the C3 position of the benzofuran scaffold in high efficiency. Directing group cleavage and further diversification of the C3‐arylated benzofuran products were then achieved in a single synthetic operation through the utilization of a one‐pot, two‐step transamidation procedure, which proceeded via the intermediate N‐acyl‐Boc‐carbamates. Given the high efficiency and modularity of this synthetic strategy, it constitutes a very attractive method for generating structurally diverse collections of benzofuran derivatives for small molecule screening campaigns.
Directing Group-Assisted Copper(II)-Catalyzed ortho-Carbonylation to Benzamide using 2,2′-Azobisisobutyronitrile (AIBN)
Khan, Bhuttu,Khan, Afsar Ali,Kant, Ruchir,Koley, Dipankar
, p. 3753 - 3758 (2016/12/16)
An efficient copper-catalyzed regioselective C—H bond carbonylation of benzamides has been developed using 2,2′-azobisisobutyronitrile (AIBN) as traceless cyanating agent. The non-toxic and readily available AIBN was used for the carbonylative cyclization
Rh-Catalyzed, Regioselective, C-H Bond Functionalization: Access to Quinoline-Branched Amines and Dimers
Reddy, M. Damoder,Fronczek, Frank R.,Watkins, E. Blake
supporting information, p. 5620 - 5623 (2016/11/17)
Rh-catalyzed, chelation-induced, C-5 regioselective C-H functionalization of 8-amidoquinolines with a range of N-Boc aminals is reported for the first time. The addition of in situ generated imines to C(sp2)-H bonds afforded branched amines in