- Syntesis of the new tricyclic system thieno pyridopyrazin-4-one
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The new tricyclic system thienopyrido(1,2-a)pyrazin-4-one, a thiophenic isostere of the heterocyclic system pyrazino(1,2-a)isoquinolin-4-one is synthesised by cyclization in acidic medium from 4-acyl-6-hydroxy-1-piperazin-
- Frehel, Daniel,Maffrand, Jean-Pierre
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p. 143 - 149
(2007/10/02)
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- NEW SYNTHESES OF PRAZIQUANTEL : 2-(CYCLOHEXYLCARBONYL)-1,2,3,6,7,11b-HEXAHYDRO-4H-PYRAZINOISOQUINOLIN-4-ONE
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This paper describes two different synthetic pathways for praziquantel, a new broad spectrum schistosomicide and cestocide.Easy to apply on an industrial scale, they involve a selective reduction of 4-acyl-1-phenethylpiperazine-2,6-dione in 4-acyl-6-hydroxy-1-phenethylpiperazin-2-one, the cyclisation of wchich in acetic medium gives tricyclic compounds 2-acyl-1,2,3,6,7,11b-hexahydro-4H-pyrazinisoquinolin-4-one.
- Frehel, Daniel,Maffrand, Jean-Pierre
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p. 1731 - 1735
(2007/10/02)
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