Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones
A new series of benzothiazine-substituted quinolinediones were evaluated as inhibitors of HCV polymerase NS5B. SAR studies on this series revealed a methyl sulfonamide group as a high affinity feature. Analogues with this group showed submicromolar potenc
de Vicente, Javier,Hendricks, Robert T.,Smith, David B.,Fell, Jay B.,Fischer, John,Spencer, Stacey R.,Stengel, Peter J.,Mohr, Peter,Robinson, John E.,Blake, James F.,Hilgenkamp, Ramona K.,Yee, Calvin,Adjabeng, George,Elworthy, Todd R.,Tracy, Jahari,Chin, Elbert,Li, Jim,Wang, Beihan,Bamberg, Joe T.,Stephenson, Rebecca,Oshiro, Connie,Harris, Seth F.,Ghate, Manjiri,Leveque, Vincent,Najera, Isabel,Pogam, Sophie Le,Rajyaguru, Sonal,Ao-Ieong, Gloria,Alexandrova, Ludmila,Larrabee, Susan,Brandl, Michael,Briggs, Andrew,Sukhtankar, Sunil,Farrell, Robert,Xu, Brian
scheme or table
p. 3642 - 3646
(2010/03/31)
Heterocyclic antiviral compounds
Compounds having the formula I wherein A, m and R1 are herein defined are Hepatitis C virus polymerase inhibitors. Also disclosed are compositions and methods for treating diseases mediated by HCV and for inhibiting hepatitis replication. Also disclosed are processes for making the compounds and synthetic intermediates used in the process
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Page/Page column 31
(2008/06/13)
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