- Isomerization kinetics of panipenem in aqueous solution
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The isomerization kinetics of panipenem (INN: (+)-(5R,6S)3-[(S)1- (acetimidoylpyrrolidin-3-yl)thiol-6[(R)-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0] hept-2-ene-2-carboxylic acid, CAS No. 87726-17-8) in aqueous solution were investigated. An equilibrium betwe
- Ito, Nobuya,Suzuki, Masahiko,Kusai, Akira,Takayama, Kozo
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- Preparation process of antibiotic drug panipenem
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The invention discloses a preparation process of an antibiotic drug panipenem. The panipenem is prepared by adopting a unique synthesis method. The problems of expensive raw materials, long production period, low yield, low purity and the like in the preparation of the existing antibiotic drug panipenem are solved. The preparation process with high efficiency, high yield, high purity, short period and low production cost is provided for synthesis of panipenem.
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Paragraph 0024-0035
(2021/06/21)
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