Synthesis of the prodrug ibuprofen β-D-glucopyranoside and its biological evaluation as a better moiety than the parent drug
β-D-Glucopyranosyl derivative 5 of ibuprofen 1 has been synthesised by condensing 2,3,4,6-tetraacetyl glucopyranosyl bromide with sodium salt of ibuprofen by modified Koenig's Knorr reaction in presence of phase transfer catalyst and subsequent deacetylat
Khan,Khan
p. 1052 - 1055
(2007/10/03)
Antiinflammatory Derivatives of Substituted Propionic Acids - I
β-Glycosides (IIIa,b) of d-Naproxen (Ia) and Ibuprofen (Ib) are prepared by treating peracetylglucosyl bromide with sodium salts of Ia and Ib using phase transfer conditions at room temperature.These compounds are screened for their pharmacological properties.
Singh, Pritpal,Hingorani, L. L.,Trivedi, G. K.
p. 337 - 338
(2007/10/02)
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