879487-75-9

Basic information

• Product Name: 4-Bromo-3-methylbenzenesulfonamide
• Synonyms: 4-Bromo-3-methylbenzenesulfonamide;2-Bromo-5-sulphamoyltoluene;BenzenesulfonaMide, 4-broMo-3-Methyl-;4-Bromo-3-methylbenzenesulphonamide99%
• CAS NO: 879487-75-9
• Molecular Formula: C7H8BrNO2S
• Molecular Weight: 250.11292
• Mol File: 879487-75-9.mol

Chemical Properties

• Melting Point: 148°C
• Appearance: /
• CAS DataBase Reference: 4-Bromo-3-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-3-methylbenzenesulfonamide(879487-75-9)
• EPA Substance Registry System: 4-Bromo-3-methylbenzenesulfonamide(879487-75-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 879487-75-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-3-methylbenzenesulfonamide is used as a key intermediate in the synthesis of acylsulfamoyl benzoxaboroles, which are known to function as inhibitors of the Hepatitis C Virus (HCV) NS3 protease. This makes it a valuable reagent in the development of antiviral drugs targeting Hepatitis C.
In the context of drug development, 4-Bromo-3-methylbenzenesulfonamide plays a crucial role in the creation of compounds that can effectively inhibit the NS3 protease enzyme, a critical component in the life cycle of the Hepatitis C virus. By inhibiting this enzyme, the replication and spread of the virus can be significantly reduced, offering a potential therapeutic approach to treating Hepatitis C infections.

Relevant articles and documents

SUBSTITUTED BIPHENYL DERIVATIVE

The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: wherein R1 represents a C6-C10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C1-C6 alkyl)amino group, a di-(C1-C6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C1-C6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R3 represents a C1-C6 alkyl group, and so on; and R4 represents a C1-C6 alkyl group, and so on.