cas 88-95-9, Phthaloyl dichloride | Articles data

Articles about 88-95-9Total 24 be found

Article title
Article abstract
Author
Journal number and time
Download

-
-
Greene
p. 1503,1506
(1959)
Read Online

Design, synthesis and molecular docking studies of novel cyclic pentapeptides based on phthaloyl chloride with expected anticancer activity
Aseries of Nα-phthaloyl bridged cyclic pentapeptide derivatives were synthesized and characterized on the basis of spectral and elemental analyses. A preliminary cytotoxicity evaluation of all novel compounds was carried out against four human cancer cell lines, human lung (A-549), colon (CaCo-2), prostate (PC-3) and breast (MCF-7) cancer cells at 100 μM concentration using MTT growth inhibition assay. Compound 3 gave the highest cytotoxic activity towards the human colon (CaCo-2) cancer cell line (Growth Inhibition = 72.4 %). Further molecular docking of the promising derivative 3 was developed to study its binding mode within the active site of EGFR enzyme. The docking results suggest good fitting through different hydrogen bond interactions with the protein residues to elicit anticancer activity.
Mohamed, Fatma H.,Shalaby, Ahmad M.,Soliman, Hanan A.,Abdelazem, Ahmed Z.,Mounier, Marwa M.,Nossier, Eman S.,Moustafa, Gaber O.
p. 1723 - 1736
(2020/09/01)

Preparation method of isoxazolidine hydrochloride
The invention belongs to the field of organic synthesis, discloses a new route and a new method for preparing a herbicide intermediate, and particularly relates to a preparation method of isoxazolidine hydrochloride. The preparation method comprises the following steps: subjecting N-hydroxyphthalimide and 1-bromo-3-chloropropane to a condensation reaction in the presence of a solvent A and an acid-binding agent; reacting the condensation product that is 2-(3-chloropropoxy) isoindole-1,3-diketone with hydrochloric acid to obtain the isoxazolidine hydrochloride. The 1-bromo-3-chloropropane is adopted in place of 1,3-dichloropropane, the content and the reaction yield of the isoxazolidine hydrochloride prepared in a proper solvent are higher than those of isoxazolidine hydrochloride preparedby a traditional method, and meanwhile, the byproduct phthalic acid can be recycled. In addition, the post-reaction treatment is simpler, so that the product loss is less. Therefore, the production energy consumption is well controlled, the pollution to the environment is reduced, and the reaction safety is improved.
-
Paragraph 0035; 0039; 0040

(2020/07/13)

Method of co-producing methyl benzoic acid, methylbenzoyl chloride and phthaloyl dichloride
The invention discloses a method of co-producing methyl benzoic acid, methylbenzoyl chloride and phthaloyl dichloride. The method comprises the following steps: (1) continuously introducing xylene, acatalyst and oxygen-containing gas into an oxidizing reactor to react to obtain an oxidized reaction solution; (2) rectifying and separating the oxidized reaction solution to obtain a low-boiling-point component and an initial evaporative tower bottom; (3) rectifying the initial evaporative tower bottom to obtain a methyl benzoic acid product and a tower bottom; (4) carrying out an acylating chlorination reaction on the tower bottom and an acylating chlorination reagent to obtain an acyl chloride reaction solution; and (5) rectifying and separating the acyl chloride reaction solution to separately obtain methylbenzoyl chloride and phthaloyl dichloride products. The method provided by the invention has the advantages of being simple in process, small in equipment investment, green and environment-friendly and good in comprehensive economical benefit.
-
Paragraph 0178; 0179; 0192-0194; 0196; 0198

(2018/06/16)

Novel bivalent securinine mimetics as topoisomerase I inhibitors
A series of novel bivalent securinine mimetics incorporating different linkers between C-15 and C-15′ were synthesized and their topoisomerase I (Topo I) inhibitory activities evaluated. It was thus revealed that mimetic R2 incorporating a rigid m-substituted benzene linker exhibits Topo I inhibitory activity three times that of parent securinine. Comprehensive structure-activity relationship analyses in combination with docking studies were used to rationalize the potent activity of these bivalent mimetics. Mechanistic studies served to confirm the deductions arising from docking studies that the active bivalent mimetics not only inhibited complexation between Topo I and DNA but also stabilized the Topo I-DNA complex itself.
Hou, Wen,Lin, Hui,Wang, Zhen-Ya,Banwell, Martin G.,Zeng, Ting,Sun, Ping-Hua,Lin, Jing,Chen, Wei-Min
p. 320 - 328
(2017/03/08)

Enhance the fluorescence and singlet oxygen generation ability of BODIPY: Modification on the meso-phenyl unit with electron withdrawing groups
Herein, meso-R-carboxyphenyl substituted BODIPY compounds were synthesized and characterized (R = CH3, COOH, NO2, H and Br4). The fluorescence, excited triplet state and singlet oxygen formation properties for these compounds were measured in nonpolar and polar solvents by UV–vis absorption, steady-state and time-resolved fluorescence methods, as well as laser flash photolysis technique. These BODIPYs exhibit very different fluorescence quantum yield and lifetime value, as well as singlet oxygen formation capability in polar solvents. In contrast, these compounds show very similar spectral shape and position, emit bright green fluorescence in non polar solvents. The introduction of an ortho-COOH on the benzene unit leads to a 20-fold increase in the fluorescence quantum yield. The further introduction of an electron withdrawing NO2 or COOH on the phenyl makes the BODIPY dye show much higher capability to generate singlet oxygen (up to 5-fold increase) and causes a sharp decrease in both fluorescence quantum yield and lifetime value. The increase in solvent polarity enhances singlet oxygen generation and intramolecular fluorescence quenching. The results are explained by the presence of intramolecular photoinduced electron/charge transfer from BODIPY core to the carboxyphenyl moiety.
Zhang, Xian-Fu,Zhang, Yakui,Xu, Baomin
p. 197 - 206
(2017/09/26)

Aromatic Esters, Carbinols, and Derivatives Thereof with Perfluorohexyl Residues as Alternatives to Perfluoroalkanecarboxylic and -sulfonic Acids
Four perfluorohexyl carbinols have been prepared from the corresponding Grignard reagent and benzaldehyde, terephthalaldehyde, isophthalaldehyde, and trimesaldehyde. The corresponding secondary alcohols were then transformed by alkylation and acylation reactions to form a total of 14 ethers (methyl, ethyl, propyl, and n-hexyl ethers) and esters (acetyl and 2-ethylhexanoyl), respectively. Furthermore, 11 perfluoroalkyl carboxylates were prepared from aromatic, heteroaromatic, and aliphatic mono-, di-, tri-, and tetracarboxylic acids and tridecafluorooctanol. The wettability of all 29 materials was investigated by the water contact angle measurements of thin films on glass surfaces. In up to six cases, contact angles greater than 130° were observed, which indicates that the products might be suitable candidates for the impregnation of surfaces. With their relatively short perfluoroalkyl side-chains and therefore low bioaccumulativity, the target compounds might be beneficial alternatives to established products.
Alpers, Torben,Muesmann, Thomas W. T.,Temme, Oliver,Christoffers, Jens
p. 609 - 617
(2017/02/05)

Synthesis and antibacterial activity of some novel piperazinophanes with an intraannular ester functionality
1:1 and 2:2 oligomeric piperazinophanes with an intraannular ester functionality have been synthesized via Mannich reaction of various aromatic esters with piperazine by a one-pot reaction under benign conditions through the multicomponent reaction methodology. The newly synthesized piperazinophanes were characterized using spectral and analytical methods. The ester based 1:1 oligomeric piperazinophanes exhibit good target binding ability in molecular docking studies and also show better antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Streptococcus pyogenes bacteria than the 2:2 oligomeric piperazinophanes.
Selvarani, Sivasamy,Rajakumar, Perumal
p. 9494 - 9499
(2016/11/11)

PROCESS FOR PREPARING SOLID (CHLORINE METHYLENE) DIMETHYL AMMONIUM CHLORIDE
Solid (chloro methylene) dimethyl ammonium chloride of in manufacturing method, said method, and phthalic anhydride raw material is first acyl with Neel thio chloride and method for chlorinating side is performed on the stacking section for stacking o-reel chloride, again chloride reel-o N, reacts with N-dimethylformamide (chloro methylene) dimethyl ammonium chloride and, and phthalic anhydride is obtained, N of increased amount of generated, and phthalic anhydride, dissolving the-dimethylformamide N, solid-liquid through separation of solid (chloro methylene) dimethyl ammonium chloride to obtain. the method number 1-step reaction through the interrupt input is an input from the data input sulfur dioxide, high vacuum under conditions protruded from sulfur dioxide and does not require the removal of, , moderating reaction conditions, to implemented very easily in.
-
Paragraph 0021-0022

(2016/12/22)

Dimeric 3,5-bis(benzylidene)-4-piperidones: A novel cluster of tumour-selective cytotoxins possessing multidrug-resistant properties
A series of bis[3,5-bis(benzylidene)-4-oxo-1-piperidinyl]amides 1 display potent cytotoxic properties towards a wide range of tumours. A number of the CC50 and IC50 values are in the range of 10-8 M. Specifically, these compounds have the following important properties. First, greater toxicity was demonstrated towards certain tumours than various non-malignant cells. Second, various compounds in series 1 are toxic to a number of human colon cancer and leukaemic cells. Third, these compounds reverse P-gp mediated multidrug resistance. Various prototypic molecules such as 1a,b and 1i were identified as lead molecules for further studies. A representative lead molecule 1b induces apoptosis via internucleosomal DNA fragmentation and PARP cleavage in HSC-2 and HL-60 cells while flow cytometry revealed that this compound blocked the G2/M and S-phases in the cell cycle of human colon cancer HCT-116 cells.
Das, Swagatika,Das, Umashankar,Sakagami, Hiroshi,Umemura, Naoki,Iwamoto, Shoko,Matsuta, Tomohiko,Kawase, Masami,Molnár, Joseph,Serly, Julianna,Gorecki, Dennis K.J.,Dimmock, Jonathan R.
supporting information; experimental part
p. 193 - 199
(2012/07/14)

Acetic anhydride mediated condensation of aromatic o-diacid dichlorides with benzimidazoles to provide electro-reducible p-dione adducts
Acetic anhydride mediates a facile and rapid condensation of benzimidazole with aromatic o-diacid dichlorides to precipitate p-dione adducts in excellent yields. Condensation with pyridine-3,4-dicarbonyl dichloride produced a 1:1 mixture of isomeric p-diones. The X-ray crystal structure of one of the latter isomers revealed unusual high density, and inter-layer separation similar to graphite. Cyclic voltammetry demonstrated that p-dione is capable of two consecutive one-electron-reductions with formal potentials influenced by the fused (hetero)aromatic and substituent effects.
Joyce, Eamonn,Kavanagh, Paul,Leech, Dónal,Karpinska, Jolanta,McArdle, Patrick,Aldabbagh, Fawaz
experimental part
p. 3788 - 3791
(2012/09/10)

Synthesis, crystal structure and biological activity of novel diester cyclophanes
A series of novel diester cyclophanes was synthesized by esterification of 1,2-benzenedicarbonyl chloride with eight different diols under high dilution conditions. The structures of the compounds were verified by elemental analysis, 1H nuclear magnetic resonance (NMR), IR spectroscopy and high resolution mass spectrometry (HRMS). The crystal structures of two compounds were characterized by single crystal X-ray diffractometry (XRD). All the new cyclophanes were evaluated for biological activities and the results showed that some of these compounds have low antibacterial or antifungal activities.
Zhang, Pengfei,Yang, Bingqin,Fang, Xianwen,Cheng, Zhao,Yang, Meipan
p. 1771 - 1775
(2013/03/13)

PROCESS FOR PRODUCTION OF PHTHALOYL DICHLORIDE COMPOUNDS, CATALYST TO BE USED THEREIN, AND PROCESS FOR PREPARATION OF SAME
A method of producing a phthaloyl dichloride compound, the method including: providing a compound represented by the following formula (1) and a compound represented by the following formula (2); and bringing the compound represented by the following formula (1) and the compound represented by the following formula (2) into reaction, so as to form a compound represented by the following formula (3), in the presence of at least one compound selected from a zirconium compound, a hafnium compound, and zinc oxide; wherein, in formulae, X represents a hydrogen atom, a halogen atom, a nitro group, a methyl group, or a methoxy group; when the X is plural, Xs may be the same or different from each other; n represents an integer of from 0 to 2; R represents a halogen atom, a chlorocarbonyl group, a low carbon number alkyl group, or a halogen-substituted low carbon number alkyl group; when the R is plural, Rs may be the same or different from each other; and m represents an integer of from 0 to 2.
-
Page/Page column 12

(2011/06/24)

Bis[3,5-bis(benzylidene)-4-oxo-1-piperidinyl]amides: A Novel Class of Potent Cytotoxins
The principal objective of this study was the examination of the theory of cytotoxic synergism. In this exploratory study, we tested the hypothesis that doubling the number of sites available for thiol alkylation in a series of candidate cytotoxins increases potency more than two-fold. This concept was verified in one-third of our comparisons using human Molt 4/C8 and CEM T-lymphocytes and murine L1210 cells. In addition, the significant potencies of various members of our compound series justified further studies. Molecular modeling revealed that relative locations of the amidic groups correlate with cytotoxicity. A potent cytotoxic compound, 1,2-bis(3,5-dibenzylidene-4-oxo-piperidin-1-yl)ethane-1,2-dione (1a) inhibited the growth of a large number of human tumor cell lines and displayed greater toxicity toward certain non-adherent cells than toward adherent neoplasms or fibroblasts. The mode of action of 1a includes induction of apoptosis and necrosis.
Das, Swagatika,Das, Umashankar,Varela-Ramirez, Armando,Lema, Carolina,Aguilera, Renato J.,Balzarini, Jan,DeClercq, Erik,Dimmock, Stephen G.,Gorecki, Dennis K. J.,Dimmock, Jonathan R.
experimental part
p. 1892 - 1899
(2012/07/03)

Synthesis and optical storage properties of a thiophene-based holographic recording medium
The results of the fabrication and optical data storage characteristics of a novel azothiophene polyester 9 for potential holographic storage are reported. The polyester is derived from an azothiophene diol 1 and diphenyl phthalate 8 via in vacuo melt transesterification. Inclusion of a 5-methoxy-2-thienyl moiety generates a trans π-π* transition centered close to 405 nm. An investigation of the optical data storage characteristics of a solution cast film of azopolyester with a thickness of 65 m is summarised. The optical anisotropy induced by a 532 nm frequency doubled YAG laser and probed at a wavelength of 633 nm outside the absorption band with a polarimeter reveals a very high induced anisotropy of 7 rad (laser intensity, 250 mW cm-2). The calculated birefringence of the film is 0.02 per micron. Maximum anisotropy is reached after approximately 70 s of irradiation. The induced anisotropy disappears at approximately 90 °C. Room temperature stable gratings can be inscribed with high diffraction efficiency. The Royal Society of Chemistry 2007.
Matharu, Avtar S.,Jeeva, Shehzad,Huddleston, Patrick R.,Ramanujam
p. 4477 - 4482
(2008/12/22)

METHOD FOR THE PRODUCTION OF PHTHALIC DICHLORIDE
Disclosed is a method for producing phthalic dichloride by reacting phthalic anhydride with a chlorinating agent (I) selected among the group comprising thionyl chloride and phosgene in the presence of a catalyst at a temperature ranging between 80 and 200 °C as well as a pressure of 0.01 to 10 MPa abs, triphenylphosphine, triphenylphosphine oxide or the mixture thereof being used as a catalyst (II).
-
Page/Page column 6; 10

(2008/06/13)

Process for the preparation of phthalic acid dichloride
Preparation of phthalic acid dichloride (I) comprises reaction of phthalic acid anhydride (II) with phosgene in presence of catalyst (N,N-disubstituted formamide (III)). Preparation of phthalic acid dichloride of formula (I) comprises reaction of phthalic acid anhydride of formula (II) with phosgene in presence of catalyst (N,N-disubstituted formamide (III) of formula (HC(O)-N(R 1>)(R 2>)). R 1>, R 2>1-22C alkyl, 2-22C alkenyl, 3-8C cycloalkyl, 6-10C aryl or 7-12C arylalkyl. Where R 1>, R 2>containing 1-22C alkyl, 2-22C alkenyl amounts to total molecular weight of (III) is at least 269 g/mol. [Image].
-
Page/Page column 5; 6

(2008/06/13)

Process for preparing phthaloyl chloride
The invention relates to a novel process for preparing phthaloyl chloride (benzene-1,2-dicarbonyl chloride) by reacting phthalic anhydride with phosgene in the presence of a specific N,N-disubstituted formamide as a catalyst.
-
Page/Page column 4

(2008/06/13)

Synthesis and characteriation of novel poly (ester amide)s containing benzthiazole heterocyclic ring
The novel Poly (ester-amide)s (PEAs) were prepared by inrter-facial polycondensation of 5 - hydroxy - 2 - amino benzthiazole with various di-basic acid chlorides. The PEAs were characterized by elements analysis, IR spectra studies, Mn estimated by non aqueous conductometric titration and thermogravimetry. The electric conductivity of all the poly (ester amide)s PEAs was also measured at room temperature and it was found that the PEAs have semiconducting properties.
Patel,Desai,Patel
p. 203 - 208
(2007/10/03)

METHOD FOR PRODUCING PHTHALIC ACID DICHLORIDE
The invention relates to a novel method for producing phthalic acid dichloride (benzol-1,2-dicarboxylic acid dichloride) from phthalic acid anhydride by reacting the same with phosgene in the presence of an N,N-dialkyl-formamide.
-
Page/Page column 7

(2008/06/13)

Novel N-cyclohexyl-polycarboxamide compound and derivatives thereof, processes for preparing them, and use of them in preparation of host-guest complexes
-
-
(2008/06/13)

N-cyclohexyl-polycarboxamide compound and derivatives thereof
This invention provides novel N-cyclohexyl-polycarboxamide compounds having inclusion power for a variety of compounds, the N-cyclohexyl-polycarboxamide compound being of the general formula STR1 where R is a benzene ring, an ethylidene group, a benzylidene group, a 1,2-cyclohexylene group, a 1,2-cyclohexenylene-4 group, or a 2,3-, 2,5- or 2,6-pyridinediyl group, and n is equal to 2, 3 or 4 when R is a benzene ring, and equal to 2 when R is one of the aforesaid groups excluding a benzene ring. These compounds exhibit the host function of taking up a variety of compounds as guest compounds to form inclusion complexes, and can be utilized for the separation and purification thereof.
-
(2008/06/13)

Cyclic Carboxylic Monophosphides: A New Class of Phosphorus Heterocycle
Bis(trimethylsilyl)phosphines, RP(SiMe3)2 (R=Ph, But), react with di-acid chlorides or the corresponding acid anhydrides to afford cyclic carboxylic monophosphides featuring five-, six-, or seven-membered phosphorus-containing rings; the reaction chemistry of the five-membered ring is discussed.
Barron, Andrew R.,Hall, Stephen W.,Cowley, Alan H.
p. 1753 - 1755
(2007/10/02)

Organotellurium Chemistry. 4. Synthesis and Reactions of Tellurophthalide. The First Alkyltellurenyl Halides
The first alkyltellurenyl halides were obtained as isoble but unstable compounds from halogenolysis of tellurophthalide (1c), a compound obtained in almost quantitative yield from 2-(bromomethyl)benzoyl chloride and sodium hydrogen telluride.The structures of the new compounds were confirmed by transformations to a single benzyl tellurocyanate that was independently synthesized.
Engman, Lars,Cava, Michael P.
p. 4194 - 4197
(2007/10/02)

Acylated derivatives of substituted piperazines and polymeric compositions stabilized thereby
Acylated derivatives of substituted piperazines are stabilizers for synthetic polymeric materials normally subject to deterioration caused by ultraviolet light. The compounds are prepared by the acylation reaction between a substituted piperazine and a mono or di-acid halide, ester or isocyanate. Polymeric compositions containing these stabilizers may also contain a hindered phenolic compound. A typical embodiment is 15-stearoyl-7,15-diazadispiro[5,1,5,3]hexadecane.
-
(2008/06/13)