- Process for synthesizing 2 - methyl -5 nitroimidazole
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The invention discloses a synthesis process of 2 - methyl -5 nitroimidazole, which comprises the following steps: (1) a synthesis reaction. (2) In neutralization, centrifugation. (3) A dry package. The step (2) further comprises a sodium nitrite recovery process. The waste water is added into a multi-effect evaporation crystallizer for concentration mother liquor, sodium nitrate is crystallized out, sodium nitrate crystals are separated through a horizontal spiral centrifugal machine, and then the sodium nitrate finished product is obtained through an airflow dryer. The process is more suitable for large-scale production, the consumption of main materials is greatly reduced, concentrated sulfuric acid is not added, the production cost is lower, and the sodium nitrate - hydrochloric acid mixed system used in the invention is more favorable for removing excess nitric acid and hydrochloric acid in the reaction liquid. The product yield reaches 97.0% or more, and the product content reaches 99.8% or more.
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Paragraph 0012-0017
(2021/10/05)
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- Heterogeneous photocatalysis of metronidazole in aquatic samples
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Metronidazole (MET) is a commonly detected contaminant in the environment. The compound is classified as poorly biodegradable and highly soluble in water. Heterogeneous photocatalysis is the most promoted water purification method due to the possibility of using sunlight and small amounts of a catalyst needed for the process. The aim of this study was to select conditions for photocatalytic removal of metronidazole from aquatic samples. The effect of catalyst type, mass, and irradiance intensity on the efficiency of metronidazole removal was determined. For this purpose, TiO2, ZnO, ZrO2, WO3, PbS, and their mixtures in a mass ratio of 1:1 were used. In this study, the transformation products formed were identified, and the mineralization degree of compound was determined. The efficiency of metronidazole removal depending on the type of catalyst was in the range of 50–95%. The highest MET conversion (95%) combined with a high degree of mineralization (70.3%) was obtained by using a mixture of 12.5 g TiO2–P25 + PbS (1:1; v/v) and running the process for 60 min at an irradiance of 1000 W m?2. Four MET degradation products were identified by untargeted analysis, formed by the rearrangement of the metronidazole and the C-C bond breaking.
- Bajkacz, Sylwia,Felis, Ewa,Kasprzyk, Patrycja,Stando, Klaudia
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supporting information
(2021/12/24)
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- Continuous synthesis method for 2-methyl-5-nitroimidazole
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The invention provides a continuous synthesis method for 2-methyl-5-nitroimidazole. The 2-methyl-5-nitroimidazole is synthesized in a micro-channel reactor. The synthesis method provided by the invention can realize continuous synthesis, is safe and stable in production process, extremely short in reaction time and high in yield, and can reduce the usage amount of concentrated sulfuric acid and lower cost.
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Paragraph 0017; 0042; 0047-0050; 0055-0058; 0063-0065
(2020/07/15)
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- Novel nitroimidazole drug as well as preparation method and application of novel nitroimidazole drug
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The invention relates to a novel nitroimidazole compound as well as a preparation method and application of the novel nitroimidazole compound to medical science and specifically relates to a nitroimidazole compound as shown in a general formula (I), a preparation method of the nitroimidazole compound and a pharmaceutical composition containing the compound. The invention aims at synthesizing a novel compound of a series of nitroimidazole derivatives by modifying the structure of a nitroimidazole compound, the compound can be used for obviously reducing adverse reaction in clinic, meanwhile, the compound has a relatively ideal effect on protecting the liver and kidneys, and the clinical application of the compound is apparent.
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Paragraph 0022
(2018/04/01)
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- Tritiated metronidazole and preparation method thereof
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The invention belongs to the field of radioactive isotope labeling preparation, and particularly relates to tritiated metronidazole and a preparation method thereof. The preparation method includes: using 2-methyl-5-nitroimidazole as a raw material to react with N-iodosuccinimide to obtain 4-iodine-2-methyl-5nitroimidazole; under catalysis of palladium carbon, enabling 4-iodine-2-methyl-5nitroimidazole and tritium gas to be in tritium-halogen exchange to generate 4-3H-2-methyl-5-nitroimidazole; enabling 4-3H-2-methyl-5-nitroimidazole to react with ethylene oxide to obtain 4-3H-metronidazole. A synthetic product is purified through a prepared liquid phase to obtain4-3H-metronidazole with high specific activity (22.08Ci/g), high radiochemical purity (greater than or equal to 98%) and high chemical purity (greater than or equal to 98%). The tritiated metronidazole can be used as a radioactive tracer in studying absorption, distribution, metabolism and residue elimination of metronidazole in animal bodies.
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Paragraph 0037; 0038
(2017/08/28)
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- Scale-up synthesis of zero-valent iron nanoparticles and their applications for synergistic degradation of pollutants with sodium borohydride
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The scale-up synthesis of nZVI (zero-valent iron nanoparticles) was optimized by response surface modeling (RSM). The synthesized nZVI was employed for synergistic degradation of metronidazole (MNZ) or methyl orange (MO) in the presence of sodium borohydr
- Ravikumar,Dubey, Swati,pulimi, Mrudula,Chandrasekaran, Natarajan,Mukherjee, Amitava
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p. 589 - 598
(2016/10/24)
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- SYNTHESIS OF METRONIDAZOLE
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The producers utilize costly and unique active ingredients to produce metronidazole synthesis which has to be imported from other countries; consequently the cost of its production rises greatly. Furthermore, this drug has side effect in the present methods of production. Overusing usual samples leads to kidney stone in the patient's body. The purpose of this invention is to remove the mentioned defects. Producing metronidazole using the new method does not require utilizing costly and unique active ingredients for the producer and production process can be done with a lower cost. In addition, its production using the new method has fewer side effects rather than the previous methods.
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Page/Page column 3
(2016/04/19)
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- Synthesis, crystal structure and antibacterial activity of new highly functionalized ionic compounds based on the imidazole nucleus
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Several new highly functionalized imidazolium derivatives were synthesized, via appropriate synthetic routes, using imidazole, 1-methylimidazole and 2-phenyl-1-methylimidazole as key intermediates. The antibacterial activity of the prepared compounds was evaluated against: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella thipymurium using disk-diffusion and MIC methods. Crystal X-ray structures are reported for six compounds.
- Bahnous, Mebarek,Bouraiou, Abdelmalek,Chelghoum, Meryem,Bouacida, Sofiane,Roisnel, Thierry,Smati, Farida,Bentchouala, Chafia,Gros, Philippe C.,Belfaitah, Ali
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p. 1274 - 1278
(2013/03/14)
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- Chemical compound suitable for use as an explosive, intermediate and method for preparing the compound
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A new compound, 1,1-diamino-2,2-dinitroethylene suitable for use as an explosive, as well as an intermediate for preparing the compound consisting of a heterocyclic 5- or 6-ring of the general formula wherein n=at least 1. The compound is prepared by nitrating a heterocyclic 5- or 6-ring containing the structural element wherein Y is an alkoxy group, with a nitrating acid at a low temperature, preferably 0-30° C., and selecting the acidity of the nitrating acid for obtaining a substantial yield of a product containing the structural element and hydrolyzing said product in an aqueous medium for separating 1,1-diamino-2,2--dinitroethylene which is recovered as a precipitate.
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- Metronidazole derivatives with intramolecular equivalents of reduction
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In the Hantzsch synthesis the aldehyde 2, obtained from metronidazole (1) by Swern oxidation, yields the dihydropyridines (DHP) 3 and 4. Compound 3 is splitted into the imidazole 5 and the pyridine 6 when treated with oxidizing agents. Reaction of 2 with methyl acetoacetate and sec. alicyclic amines affords the cyclohexadiene amines 7. In the same manner the diene amine 9 is formed from the imidazolecarbaldehyde 8 and morpholine, while working with catalytic amounts of piperidine the cyclohexanone 10 can be isolated.
- Goì?rlitzer, Klaus,Klanck
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p. 889 - 892
(2007/10/03)
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- Synthesis and reactions of 1,1-diamino-2,2-dinitroethylene
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Low temperature nitrations of 2-methylimidazole gave in addition to the known 2-methyl-5(4)-nitroimidazole (1), 2- (dinitromethylene)-5,5-dinitro-4- imidazolidinone (3) and parabanic acid (2). The tetranitro compound 3 was also obtained by nitration of 2-methyl-4,5-dihydro-(1H)-5-imidazolone (8). Thermal decomposition of 3 gave 2-(dinitromethylene)-4,5-imidazolidinedione (4) which also was the product from nitration of the new compound 2-methoxy- 2-methyl-4,5- imidazolidinedione. Treatment of 4 with aqueous ammonia gave the previously unknown 1,1-diamino-2,2-dinitroethylene (5). The physical properties and chemical behaviour of (5) are described.
- Latypov, Nikolai V.,Bergman, Jan,Langtet, Abraham,Wellmar, Ulf,Bemm, Ulf
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p. 11525 - 11536
(2007/10/03)
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