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88069-67-4

Pilsicainide is a class I antiarrhythmic drug that is specifically used to treat cardiac arrhythmias, particularly paroxysmal atrial fibrillation. It functions by inhibiting sodium channels in the heart, which results in a reduction of conduction and excitability of cardiac tissue. This mechanism helps to prevent the rapid and irregular heartbeats characteristic of atrial fibrillation and aids in restoring a normal heart rhythm. Pilsicainide is administered orally and has a relatively fast onset of action, making it a valuable option for the acute treatment of atrial fibrillation episodes. However, like many antiarrhythmic drugs, it can cause proarrhythmic effects, necessitating close monitoring of cardiac function during treatment.

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  • 88069-67-4 Structure

  • Basic information

    1. Product Name: PILSICAINIDE
    2. Synonyms: PILSICAINIDE;PILSICAININIDE;PILSICAINIDE(FORRESEARCHONLY);N-(2，6-Dimethylphenyl)tetrahydro-1H-pyrrolizine-7α(5H)-acetamide;SUN-1165;Sunrhythm;N-(2,6-Dimethylphenyl)-2,3,6,7-tetrahydro-1H-pyrrolizine-7a(5H)-acetamide;N-(2,6-Dimethylphenyl)tetrahydro-1H-pyrrolizine-7a(5H)-acetamide
    3. CAS NO:88069-67-4
    4. Molecular Formula: C17H24N2O
    5. Molecular Weight: 272.39
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 88069-67-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 416.9 °C at 760 mmHg
    3. Flash Point: 205.9 °C
    4. Appearance: /
    5. Density: 1.11 g/cm3
    6. Vapor Pressure: 3.7E-07mmHg at 25°C
    7. Refractive Index: 1.581
    8. Storage Temp.: room temp
    9. Solubility: N/A
    10. CAS DataBase Reference: PILSICAINIDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: PILSICAINIDE(88069-67-4)
    12. EPA Substance Registry System: PILSICAINIDE(88069-67-4)

  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 88069-67-4(Hazardous Substances Data)

88069-67-4 Usage

Uses

Used in Cardiology:
Pilsicainide is used as an antiarrhythmic agent for the treatment of cardiac arrhythmias, specifically targeting paroxysmal atrial fibrillation. It is administered orally and works by inhibiting sodium channels in the heart, thereby reducing the conduction and excitability of cardiac tissue. This action helps to prevent the rapid and irregular heartbeats associated with atrial fibrillation and assists in restoring a normal heart rhythm. Due to its fast onset of action, pilsicainide is particularly useful for the acute treatment of atrial fibrillation episodes. However, its use requires careful monitoring to manage potential proarrhythmic effects and ensure the safety and efficacy of treatment.

Check Digit Verification of cas no

The CAS Registry Mumber 88069-67-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,0,6 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 88069-67:
(7*8)+(6*8)+(5*0)+(4*6)+(3*9)+(2*6)+(1*7)=174
174 % 10 = 4
So 88069-67-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H24N2O/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20)

88069-67-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide

1.2 Other means of identification

Product number -
Other names Pilzicainide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:88069-67-4 SDS

88069-67-4Downstream Products

88069-67-4Relevant articles and documents

New Anthiarrythmic Agents. N-Aryl-8-pyrrolizidinealkanamides

Miyano, Seiji,Sumoto, Kunihiro,Satoh, Fumio,Shima, Keiyu,Hayashimatsu, Mariko,et al.

, p. 714 - 717 (2007/10/02)

The synthesis and antiarrhytmic activity of N-aryl-8-pyrrolizidinealkanamides are described.The targed compounds were evaluated for their ability to protect against chloroform-induced fibrillation in mice.Many of them were found to have antifibrillatory activity comparable to that of lidocaine; several are more potent than lidocaine.N-(2,6-Dimethylphenyl)-8-pyrrolizidineacetamide (6n), which was found to be more potent and less toxic (LD50) than lidocaine, also showed a long duration of action in dogs with venticular arrhythmias after oral administration.

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