Modulation of cAMP levels has been linked to insulin secretion in preclinical animal models and in humans. The high expression of PDE-10A in pancreatic islets suggested that inhibition of this enzyme may provide the necessary modulation to elicit increase
Cantin, Louis-David,Magnuson, Steven,Gunn, David,Barucci, Nicole,Breuhaus, Marina,Bullock, William H.,Burke, Jennifer,Claus, Thomas H.,Daly, Michelle,DeCarr, Lynn,Gore-Willse, Ann,Hoover-Litty, Helana,Kumarasinghe, Ellalahewage S.,Li, Yaxin,Liang, Sidney X.,Livingston, James N.,Lowinger, Timothy,MacDougall, Margit,Ogutu, Herbert O.,Olague, Alan,Ott-Morgan, Ronda,Schoenleber, Robert W.,Tersteegen, Adrian,Wickens, Philip,Zhang, Zhonghua,Zhu, Jian,Zhu, Lei,Sweet, Laurel J.
PHENYL-SUBSTITUTED QUINOLINE AND QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF DIABETES
The invention relates to 2-phenyl-substituted quinoline and quinazoline compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
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(2010/10/20)
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