- d-Fructose Based Spiro-Fused PHOX Ligands: Palladium Complexes and Application in Catalysis
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Phosphinooxazoline (PHOX) ligands are an important class of ligands in asymmetric catalysis. Recently we reported on the synthesis of d-fructose based spiro-fused PHOX ligands. Here, we now present the application of these ligands in asymmetric alkylation
- Imrich, Michael R.,Maichle-M?ssmer, C?cilia,Ziegler, Thomas
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supporting information
p. 3955 - 3963
(2019/07/03)
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- Preparation and Application of Amino Phosphine Ligands Bearing Spiro[indane-1,2′-pyrrolidine] Backbone
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P,Nsp3-bidentate chiral ligands bearing spiro[indane-1,2′-pyrrolidine] backbone were prepared in gram scale for the first time. Pd complexes of these air-stable amino phosphine ligands could catalyze asymmetric allylic substitutions of malonate-, alcohol-, and amine-type nucleophiles in up to 97percent ee and 99percent yield. A crystal structure of [Pd(II)(η3-1,3-diphenylallyl)(ligand)]PF6 indicated possible transition states of the catalytic reactions. These ligands are characteristic of a very rigid backbone, which is simple but highly effective. They rival C2-symmetric bisphosphine, P,Nsp2-bidentate, and P,Nsp3-bidentate ligands in tested allylic substitutions. ?
- Feng, Lifei,Jiao, Peng,Li, Hongjie,Li, Shasha,Zhang, Jinxia
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p. 9460 - 9473
(2019/08/26)
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- Use of zinc enolate, free from other metals, in enantioselective palladium-catalyzed allylic alkylation
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Zinc enolate, free from other metal cations directly prepared from malonate and diethylzinc, was proven to be an excellent nucleophile for enantioselective palladium-catalyzed allylic alkylation, particularly for the allylic cation bearing aromatic rings
- Kinoshita, Naosumi,Kawabata, Takeo,Tsubaki, Kazunori,Bando, Masahiko,Fuji, Kaoru
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p. 1756 - 1763
(2007/10/03)
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