Synthesis and A1 and A(2A) adenosine binding activity of some pyrano[2,3-c]pyrazol-4-ones
A series of pyrano[2,3-c]pyrazol-4-ones was synthesized and evaluated for bovine brain adenosine A1 and A(2A) receptor binding affinity. Substituents at positions 5 and/or 6 were varied in order to define the structure-activity relationships in
Colotta, Vittoria,Catarzi, Daniela,Varano, Flavia,Melani, Fabrizio,Filacchioni, Guido,Cecchi, Lucia,Trincavelli, Letizia,Martini, Claudia,Lucacchini, Antonio
p. 189 - 196
(2007/10/03)
Synthesis of Some 4-Oxo-1-phenyl-5,6-dihydro-1H,4H-pyranopyrazole Derivatives