- Stereoselective synthesis of 2,4-methanoproline homologues
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The stereoselective synthesis of 2-azabicyclo[2.2.1]heptane-1-carboxylic acid and 6-azabicyclo[3.2.1]octane-5-carboxylic acid, novel rigid bicyclic proline analogues, is reported. The synthesis was performed in five steps from the corresponding 2-cycloalk
- Grygorenko, Oleksandr O.,Artamonov, Oleksiy S.,Palamarchuk, Gennady V.,Zubatyuk, Roman I.,Shishkin, Oleg V.,Komarov, Igor V.
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- One-pot synthesis of α-aminonitriles from alkyl and aryl cyanides: a Strecker reaction via aldimine alanes
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A one-pot Strecker reaction using various alkyl, arylalkyl and arylnitriles is developed. Aldimine alanes were generated in situ from nitriles by the addition of diisobutylaluminium hydride, and were converted into the corresponding imines on reaction wit
- Sipos, Szabolcs,Jablonkai, István
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experimental part
p. 1844 - 1846
(2009/07/17)
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- NOVEL INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
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A compound having the structure set forth in Formula (I): wherein the variables Y, R1, R2, R3, R4 and R5 are as defined herein. Compounds described herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of such compounds and pharmaceutical compositions to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity
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Page/Page column 46-47
(2009/04/24)
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